| UniProt/SwissProt ID: | TIE1_HUMAN |
| Description: | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [Source:HGNC Symbol;Acc:11809] |
| Location: | chr1 p34.2 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1007 | RGEEVyVKKTM | Pkinase_Tyr | PhosphoSitePlus |
| S599 | RENVSsPQART | fn3 | PhosphoSitePlus |
| Y912 | CKNRGyLYIAI | HPRD | |
| Y1030 | LNYSVyTTKSD | Pkinase_Tyr | PhosphoSitePlus |
| T1032 | YSVYTtKSDVW | Pkinase_Tyr | PhosphoSitePlus |
| S472 | PLVSFsGDGPI | fn3 | PhosphoSitePlus |
| T1031 | NYSVYtTKSDV | Pkinase_Tyr | PhosphoSitePlus |
| S598 | RRENVsSPQAR | fn3 | PhosphoSitePlus |
| T604 | SPQARtALLTG | fn3 | PhosphoSitePlus |
| Y1083 | CDDEVyELMRQ | Pkinase_Tyr | PhosphoSitePlus |
| T540 | PTLMTtDCPEP | PhosphoSitePlus | |
| T1011 | VYVKKtMGRLP | Pkinase_Tyr | PhosphoSitePlus |
| Y1027 | IESLNySVYTT | Pkinase_Tyr | PhosphoSitePlus |
| T663 | SEIQLtWKHPE | fn3 | PhosphoSitePlus |
| Y912 | CKNRGyLYIAI | Pkinase_Tyr | PhosphoSitePlus |
| S516 | PKTGYsVRVQL | HPRD | |
| S478 | GDGPIsTVRLH | fn3 | PhosphoSitePlus |
| T539 | PPTLMtTDCPE | PhosphoSitePlus | |
| T608 | RTALLtGLTPG | fn3 | PhosphoSitePlus |
| Dephosphorylation site |
| TIE1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361554 | V765M | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 |
| Differential expressed protein |
| TIE1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TIE1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANGP1_HUMAN | TIE1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| TIE1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045026 | plasma membrane fusion | IEA | biological_process |
| GO:0032526 | response to retinoic acid | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016525 | negative regulation of angiogenesis | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007498 | mesoderm development | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030336 | negative regulation of cell migration | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004714 | transmembrane receptor protein tyrosine kinase act | IEA | molecular_function |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |