Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TGM2_HUMAN
Description:transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [Source:HGNC Symbol;Acc:11778]
Location:chr20 q11.23
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T368EKSEGtYCCGPPhosphoSitePlus
Y219RSSPVyVGRVVPhosphoSitePlus; HPRD; phosphoELM
S427VGLKIsTKSVGPhosphoSitePlus
S212AGRDCsRRSSPPhosphoSitePlus
S216CSRRSsPVYVGPhosphoSitePlus; HPRD
S215DCSRRsSPVYVPhosphoSitePlus
Y369KSEGTyCCGPVPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
TGM2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355330G660VSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000355330R48CCOSMICSkin Cancer21984974
ENSP00000355330G660VHPIColorectal Cancer16959974
ENSP00000355330Q69PCOSMICOvarian Cancer21720365
ENSP00000355330R262PCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000355330Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.318646787
ENSP00000355330Hepatocellular CarcinomaNormal vs. Cancercell lineUp3518646787
ENSP00000355330Gastric CancerMetastasiscell lineDown17022644
ENSP00000355330Breast CancerNormal vs. Cancercell lineDown0.1517022634
ENSP00000355330Hepatocellular CarcinomaMetastasiscell lineUp1.519016532
ENSP00000355330Gastric CancerMetastasiscell lineDown17022644
ENSP00000355330Breast CancerNormal vs. Cancercell lineUp7.920198662
ENSP00000355330Pancreatic CancerNormal vs. CancertissueUp215526344
ENSP00000355330Pancreatic CancerNormal vs. CancertissueUp2.816230073

Hyperphosphorylation site
TGM2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TGM2_HUMANGPR56_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05016Huntington's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0051482elevation of cytosolic calcium ion concentration iIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006917induction of apoptosisIEAbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0018149peptide cross-linkingIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0043277apoptotic cell clearanceIDAbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0003810protein-glutamine gamma-glutamyltransferase activiIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0060662salivary gland cavitationIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0018153isopeptide cross-linking via N6-(L-isoglutamyl)-L-IEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045785positive regulation of cell adhesionIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component


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