Phosphorylation

Protein information

UniProt/SwissProt ID:	TF_HUMAN
Description:	coagulation factor III (thromboplastin, tissue factor) [Source:HGNC Symbol;Acc:3541]
Location:	chr1 p21.3
Node attribute:	receptor

Position	PhosphoPeptide	Catalytic kinase	Source
S290	SWKENsPLN		HPRD; phosphoELM
S285	AGVGQsWKENS		HPRD; phosphoELM
S285	AGVGQsWKENS	stn_TNFRSF12A; Baculo_11_	PhosphoSitePlus
S290	SWKENsPLNVS	Baculo_11_kDa	PhosphoSitePlus
S290	SWKENsPLN	PKC_group	phosphoELM
S295	SPLNVs_____		PhosphoSitePlus
S285	AGVGQsWKENS	PKC_group	phosphoELM

TF_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000359226	Y103S	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000334145	Y103S	BIOMART	Breast Cancer	21930507, 21930502

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000359226	Renal Cancer	Normal vs. Cancer	tissue	Down		19164279

TF_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
FA7_HUMAN	TF_HUMAN	ligand -> receptor	HPMR

KEGG Pathway

KEGG ID	Pathway
hsa04610	Complement and coagulation cascades

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0051897	positive regulation of protein kinase B signaling	IMP	biological_process
GO:0031233	intrinsic to external side of plasma membrane	IC	cellular_component
GO:0045766	positive regulation of angiogenesis	IDA	biological_process
GO:0050927	positive regulation of positive chemotaxis	IC	biological_process
GO:0002020	protease binding	IPI	molecular_function
GO:0007596	blood coagulation	TAS	biological_process
GO:0006919	activation of cysteine-type endopeptidase activity	IDA	biological_process
GO:0005543	phospholipid binding	IDA	molecular_function
GO:0002543	activation of blood coagulation via clotting casca	IC	biological_process
GO:0043066	negative regulation of apoptotic process	TAS	biological_process
GO:0043498	cell surface binding	IDA	molecular_function
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0010641	positive regulation of platelet-derived growth fac	IDA	biological_process
GO:0016021	integral to membrane	IEA	cellular_component
GO:0007598	blood coagulation, extrinsic pathway	TAS	biological_process
GO:0001938	positive regulation of endothelial cell proliferat	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0002541	activation of plasma proteins involved in acute in	IDA	biological_process
GO:0005615	extracellular space	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0030335	positive regulation of cell migration	TAS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network