| UniProt/SwissProt ID: | TFPI1_HUMAN |
| Description: | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [Source:HGNC Symbol;Acc:11760] |
| Location: | chr2 q32.1 |
| Node attribute: | ligand; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S30 | PLNADsEEDEE | CK2_alpha | phosphoELM |
| S30 | PLNADsEEDEE | PhosphoSitePlus | |
| S30 | PLNADsEEDEE | CK2a1(CK2 alpha | RegPhos |
| Dephosphorylation site |
| TFPI1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000386344 | Y226* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000386344 | F240C | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| TFPI1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TFPI1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TFPI1_HUMAN | VLDLR_HUMAN | ligand -> receptor | HPMR |
| CSK21_HUMAN | TFPI1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0010466 | negative regulation of peptidase activity | IEA | biological_process |
| GO:0007598 | blood coagulation, extrinsic pathway | TAS | biological_process |
| GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
| GO:0031225 | anchored to membrane | IEA | cellular_component |
| GO:0010951 | negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0030414 | peptidase inhibitor activity | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004866 | endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0031090 | organelle membrane | IEA | cellular_component |
| GO:0007596 | blood coagulation | IEA | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |