| UniProt/SwissProt ID: | TFF2_HUMAN |
| Description: | trefoil factor 2 [Source:HGNC Symbol;Acc:11756] |
| Location: | chr21 q22.3 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y93 | RRNCGyPGISP | Trefoil | PhosphoSitePlus |
| Dephosphorylation site |
| TFF2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000291526 | R4* | COSMIC | Pancreatic Cancer | |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000291526 | hepatitis C virus | Normal vs. Cancer | cell line | Up | 17928924 | |
| Hyperphosphorylation site |
| TFF2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GATA6_HUMAN | TFF2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TFF2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IEA | biological_process |
| GO:0007586 | digestion | TAS | biological_process |
| GO:0031723 | CXCR4 chemokine receptor binding | IEA | molecular_function |
| GO:0043031 | negative regulation of macrophage activation | IEA | biological_process |
| GO:0070098 | chemokine-mediated signaling pathway | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0050728 | negative regulation of inflammatory response | IEA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0060455 | negative regulation of gastric acid secretion | IEA | biological_process |
| GO:0030334 | regulation of cell migration | IEA | biological_process |
| GO:0019722 | calcium-mediated signaling | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |