| UniProt/SwissProt ID: | TESK1_HUMAN |
| Description: | testis-specific kinase 1 [Source:HGNC Symbol;Acc:11731] |
| Location: | chr9 p13.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S220 | LAVVGsPYWMA | TESK1 | HPRD; RegPhos |
| S441 | RSLPSsPELPR | PhosphoSitePlus | |
| S220 | LAVVGsPYWMA | phosphoELM; RegPhos | |
| S220 | LAVVGsPYWMA | autocatalysis | RegPhos |
| S553 | ERTEPsPPPSA | PhosphoSitePlus | |
| S437 | ARRCRsLPSSP | PhosphoSitePlus | |
| S69 | GAGFFsEVYKV | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| TESK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000338127 | H539Y | Sjoblom2006, HPI, BIOMART, Greenman2007 | Breast Cancer | 15908952, 16959974, 17344846, 18428421, 21930507, 21930502, 16959974, 17344846, 16959974 17344846 | ENSP00000338127 | A160G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000338127 | A252S | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TESK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TESK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TESK1_HUMAN | TESK1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | TESK1_HUMAN | kinase -> substrate | RegPhos |
| TESK1_HUMAN | COF1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| TESK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0034329 | cell junction assembly | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |