Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TERF1_HUMAN
Description:telomeric repeat binding factor (NIMA-interacting) 1 [Source:HGNC Symbol;Acc:11728]
Location:chr8 q21.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S367IPVSKsQPVTPPhosphoSitePlus
S434KLKLIsSDSEDPhosphoSitePlus
S296LDTRKsVSDKQTRAP-gammaPhosphoSitePlus
T122ACQLRtIYICQTRFPhosphoSitePlus
S417LISSDsHPRD
T344ERRVGtPQSTKPhosphoSitePlus
S435LKLISsDSED_PhosphoSitePlus
T273RTRTItSQDKPTRAP-gammaPhosphoSitePlus
S266AKVVEsKRTRTTRF; TRAP-gammaPhosphoSitePlus
S437LISSDsHPRD; phosphoELM
S434KLKLIsSDSHPRD; phosphoELM
T254SEKSStFLMKATRF; TRAP-gammaPhosphoSitePlus
S252VLSEKsSTFLMTRF; TRAP-gammaPhosphoSitePlus
S435LKLISsDSHPRD; phosphoELM
T358ESRRAtESRIPPhosphoSitePlus
S11SSAAPsPRGCAPhosphoSitePlus; HPRD; SysPTM
S437LISSDsED___PhosphoSitePlus
S219LLMIIsQKDTFTRF; TRAP-gammaPhosphoSitePlus
S219LLMIIsQKDTFATMHPRD; phosphoELM; RegPhos
S415LKLISsDSHPRD
S414KLKLIsSDSHPRD
S11SSAAPsPRRCAphosphoELM; RegPhos; SysPTM
T311ESSEGtVSLLRTRAP-gammaPhosphoSitePlus
S347VGTPQsTKKKKPhosphoSitePlus
S308AVTESsEGTVSTRAP-gammaPhosphoSitePlus
S253LSEKSsTFLMKTRF; TRAP-gammaPhosphoSitePlus
T371KSQPVtPEKHRPhosphoSitePlus

Dephosphorylation site
TERF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000276602P150SCOSMICMelanoma
ENSP00000276602I272LBIOMARTBrain Cancer21930507, 21930502

Differential expressed protein
TERF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TERF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTERF1_HUMANkinase -> substrateRegPhos
FAK1_HUMANTERF1_HUMANkinase -> substrateRobert H Newman (2013)
ATM_HUMANTERF1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
TERF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008156negative regulation of DNA replicationIDAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0010521telomerase inhibitor activityIGImolecular_function
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0007067mitosisIEAbiological_process
GO:0000784nuclear chromosome, telomeric regionIEAcellular_component
GO:0006917induction of apoptosisIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000783nuclear telomere cap complexIDAcellular_component
GO:0045840positive regulation of mitosisIMPbiological_process
GO:0007004telomere maintenance via telomeraseNASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0051974negative regulation of telomerase activityIGIbiological_process
GO:0010834telomere maintenance via telomere shorteningIMPbiological_process
GO:0042493response to drugIEAbiological_process
GO:0005819spindleIDAcellular_component
GO:0003691double-stranded telomeric DNA bindingIDAmolecular_function
GO:0008301DNA binding, bendingIDAmolecular_function
GO:0032211negative regulation of telomere maintenance via teIGIbiological_process
GO:0005634nucleusIDAcellular_component
GO:0032214negative regulation of telomere maintenance via seNASbiological_process
GO:0000783nuclear telomere cap complexIEAcellular_component
GO:0008656cysteine-type endopeptidase activator activity invIDAmolecular_function
GO:0001309age-dependent telomere shorteningIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000086G2/M transition of mitotic cell cycleIEPbiological_process
GO:0007094mitotic cell cycle spindle assembly checkpointIMPbiological_process
GO:0008017microtubule bindingIDAmolecular_function
GO:0000723telomere maintenanceTASbiological_process
GO:0051260protein homooligomerizationIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0042162telomeric DNA bindingIDAmolecular_function
GO:0031116positive regulation of microtubule polymerizationIDAbiological_process
GO:0000781chromosome, telomeric regionIDAcellular_component
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0042803protein homodimerization activityIPImolecular_function
GO:0003677DNA bindingNASmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005737cytoplasmIEAcellular_component


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