Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TERA_HUMAN
Description:valosin containing protein [Source:HGNC Symbol;Acc:12666]
Location:chr9 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S775SFRFPsGNQGGHPRD
S775SFRFPsGNQGGDNA_ligase_A_CPhosphoSitePlus
S457FRWALsQSNPSPhosphoSitePlus
T688SGADLtEICQRDNA_ligase_A_CPhosphoSitePlus
T623FIIGAtNRPDIAAAPhosphoSitePlus
Y173TDPSPyCIVAPCDC48_2PhosphoSitePlus
Y143YFLEAyRPIRKCDC48_2PhosphoSitePlus
S3ADSKHPRD; SysPTM
S770SRGFGsFRFPSDNA_ligase_A_CPhosphoSitePlus
T347IVMAAtNRPNSAAAPhosphoSitePlus
S683MTNGFsGADLTDNA_ligase_A_CPhosphoSitePlus
T385ILQIHtKNMKLPhosphoSitePlus
T613MDGMStKKNVFHPRD
S541QANFIsIKGPEAAAPhosphoSitePlus
T679FLAKMtNGFSGDNA_ligase_A_CPhosphoSitePlus
T791GSGGGtGGSVYPhosphoSitePlus
Y138VYLKPyFLEAYCDC48_2PhosphoSitePlus
Y644LDQLIyIPLPDAAAPhosphoSitePlus
S101LGDVIsIQPCPCDC48_NPhosphoSitePlus
S787GPSQGsGGGTGPhosphoSitePlus; HPRD; SysPTM
S7ASGADsKGDDLPhosphoSitePlus
S352TNRPNsIDPALAAAPhosphoSitePlus
S746RFARRsVSDNDphosphoELM
S555MWFGEsEANVRAAAPhosphoSitePlus
T436DLEDEtIDAEVPhosphoSitePlus; HPRD; SysPTM
Y244RGILLyGPPGTAAAPhosphoSitePlus
T797GGSVYtEDNDDPhosphoSitePlus
S702LAIREsIESEIDNA_ligase_A_CPhosphoSitePlus
T14GDDLStAILKQPhosphoSitePlus
S13KGDDLsTAILKPhosphoSitePlus
S459WALSQsNPSALPhosphoSitePlus
S197EDEEEsLNEVGPhosphoSitePlus
Y796TGGSVyTEDNDPhosphoSitePlus
S612EMDGMsTKKNVAAAPhosphoSitePlus
S3___MAsGADSKPhosphoSitePlus; SysPTM
T606INQILtEMDGMAAAPhosphoSitePlus
S326ERRIVsQLLTLAAAPhosphoSitePlus
T330VSQLLtLMDGLAAAPhosphoSitePlus
S784GGAGPsQGSGGPhosphoSitePlus; HPRD; phosphoELM
S511FGMTPsKGVLFPhosphoSitePlus
S664ANLRKsPVAKDDNA_ligase_A_CPhosphoSitePlus
T509LKFGMtPSKGVPhosphoSitePlus; HPRD; SysPTM
Y805NDDDLyG____PhosphoSitePlus; SysPTM
S794GGTGGsVYTEDPhosphoSitePlus
S284AGESEsNLRKAAAAPhosphoSitePlus
S37INEDNsVVSLSCDC48_NPhosphoSitePlus
S282KLAGEsESNLRAAAPhosphoSitePlus
S73VCIVLsDDTCSCDC48_NPhosphoSitePlus
S352TNRPNsIDPALphosphoELM
Y755NDIRKyEMFAQDNA_ligase_A_C; Vps4_CPhosphoSitePlus
S746RFARRsVSDNDDNA_ligase_A_C; Vps4_CPhosphoSitePlus
T613MDGMStKKNVFAAAPhosphoSitePlus
T249YGPPGtGKTLIAAAPhosphoSitePlus
S276GPEIMsKLAGEAAAPhosphoSitePlus
S765QTLQQsRGFGSDNA_ligase_A_CPhosphoSitePlus
S748ARRSVsDNDIRDNA_ligase_A_C; Vps4_CPhosphoSitePlus
T56LFRGDtVLLKGCDC48_NPhosphoSitePlus
T375GIPDAtGRLEIPhosphoSitePlus
Y495QELVQyPVEHPPhosphoSitePlus
S705RESIEsEIRREDNA_ligase_A_CPhosphoSitePlus
S748ARRSVsDNDIRphosphoELM
T168FKVVEtDPSPYCDC48_2PhosphoSitePlus
Y805NDDDLHPRD; phosphoELM; SysPTM
S652LPDEKsRVAILPhosphoSitePlus
Y110CPDVKyGKRIHPhosphoSitePlus
T525PGCGKtLLAKAAAAPhosphoSitePlus
T761EMFAQtLQQSRDNA_ligase_A_C; Vps4_CPhosphoSitePlus
T316PKREKtHGEVEAAAPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y796GGTGGSVyTEDNDDDPTPN3HPRD
Y805EDNDDDLyGPTPN3HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351777I369VCOSMICHead and Neck Cancer21798897
ENSP00000351777P571SCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351777Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.118646787
ENSP00000351777Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000351777Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp1.417152098
ENSP00000351777colorectal cancerNormal vs. CancertissueUp1.314997500
ENSP00000351777Breast CancerNormal vs. CancertissueUp18257521
ENSP00000351777hepatitis B virusNormal vs. CancertissueUp2.514654528
ENSP00000351777Hepatocellular CarcinomaNormal vs. CancertissueDown0.1314654528
ENSP00000351777Lung CancerCancer vs. Cancercell lineDown17284061
ENSP00000351777Lung CancerTreatment (none vs transfected with pc3.1-hPNAS5)cell lineDown19795389
ENSP00000351777Gastric CancerNormal vs. CancertissueUp15789341
ENSP00000351777Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000351777Breast CancerNormal vs. Cancercell lineDown0.7620052998
ENSP00000351777Breast CancerNormal vs. Cancercell lineUp1.420052998
ENSP00000351777Breast CancerMetastasiscell lineUp1.820052998
ENSP00000351777Breast CancerNormal vs. CancertissueUp1.720087651
ENSP00000351777Breast CancerNormal vs. CancertissueUp2.220087651
ENSP00000351777Breast CancerNormal vs. Cancercell lineUp1.320543960
ENSP00000351777Breast CancerNormal vs. Cancercell lineUp1.420543960
ENSP00000351777Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000351777Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.9119714814

Hyperphosphorylation site
TERA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PTN3_HUMANTERA_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05134Legionellosis
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031334positive regulation of protein complex assemblyIDAbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0070842aggresome assemblyIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0032403protein complex bindingIEAmolecular_function
GO:0000502proteasome complexIDAcellular_component
GO:0045184establishment of protein localizationTASbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0006888ER to Golgi vesicle-mediated transportIEAbiological_process
GO:0045732positive regulation of protein catabolic processIDAbiological_process
GO:0031593polyubiquitin bindingIEAmolecular_function
GO:0006310DNA recombinationIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0018279protein N-linked glycosylation via asparagineIMPbiological_process
GO:0035861site of double-strand breakIDAcellular_component
GO:0043231intracellular membrane-bounded organelleISScellular_component
GO:0016887ATPase activityIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0043161proteasomal ubiquitin-dependent protein catabolic NASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0019904protein domain specific bindingIPImolecular_function
GO:0030970retrograde protein transport, ER to cytosolIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016567protein ubiquitinationNASbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0006281DNA repairNASbiological_process
GO:0009378four-way junction helicase activityIEAmolecular_function
GO:0006302double-strand break repairIDAbiological_process
GO:0006200ATP catabolic processIEAbiological_process
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0032436positive regulation of proteasomal ubiquitin-depenIEAbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0008289lipid bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0019985translesion synthesisIMPbiological_process
GO:0030433ER-associated protein catabolic processTASbiological_process