Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TEBP_HUMAN
Description:prostaglandin E synthase 3 (cytosolic) [Source:HGNC Symbol;Acc:16049]
Location:chr12 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S85GESGQsWPRLTPhosphoSitePlus; HPRD
S113DWEDDsDEDMSPkinase_CPhosphoSitePlus; SysPTM
S113DWEDDsDEDMSHPRD; phosphoELM; RegPhos; SysPTM
S118SDEDMsNFDRFCK2a1(CK2 alphaRegPhos; SysPTM
S124NFDRFsEMMNNHPRD
S148GADDDsQDSDDPkinase_CPhosphoSitePlus; SysPTM
S124NFDRFsEMMNNPkinase_CPhosphoSitePlus
S118SDEDMsNFDRFCK2_alphaphosphoELM; SysPTM
S148GADDDsQDSDDHPRD; phosphoELM; RegPhos; SysPTM
S151DDSQDsDDEKMPkinase_CPhosphoSitePlus; SysPTM
S118SDEDMsNFDRFPkinase_CPhosphoSitePlus; SysPTM
S100KLNWLsVDFNNHPRD
S151DDSQDsDDEKMHPRD; phosphoELM; RegPhos; SysPTM
S113DWEDDsDEDMSCK2_alphaphosphoELM; SysPTM
Y14YDRRDyVFIEFCSPhosphoSitePlus
S118SDEDMsNFDRFHPRD; phosphoELM; RegPhos; SysPTM
S113DWEDDsDEDMSCK2a1(CK2 alphaRegPhos; SysPTM

Dephosphorylation site
TEBP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262033H66PBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262033Prostate CancerMetastasiscell lineDown0.1415102926
ENSP00000262033Prostate CancerMetastasistissueUp3.118553995
ENSP00000262033Hepatocellular CarcinomaTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)tissueDown17593366
ENSP00000262033Breast CancerNormal vs. Cancercell lineUp1.620052998
ENSP00000262033Breast CancerNormal vs. Cancercell lineUp1.220052998
ENSP00000262033Breast CancerMetastasiscell lineDown0.7220052998
ENSP00000262033Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineUp1.815169874
ENSP00000262033Uterine CancerTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)cell lineUp19179759

Hyperphosphorylation site
TEBP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTEBP_HUMANkinase -> substrateRegPhos
CSK21_HUMANTEBP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa00590Arachidonic acid metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070389chaperone cofactor-dependent protein refoldingIDAbiological_process
GO:0051082unfolded protein bindingIDAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0000723telomere maintenanceTASbiological_process
GO:0001516prostaglandin biosynthetic processIEAbiological_process
GO:0050220prostaglandin-E synthase activityIDAmolecular_function
GO:0005697telomerase holoenzyme complexIDAcellular_component
GO:0000781chromosome, telomeric regionICcellular_component
GO:0007165signal transductionTASbiological_process
GO:0003720telomerase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23