| UniProt/SwissProt ID: | TEAD1_HUMAN |
| Description: | TEA domain family member 1 (SV40 transcriptional enhancer factor) [Source:HGNC Symbol;Acc:11714] |
| Location: | chr11 p15.3 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y76 | ELIARyIKLRT | TEA | PhosphoSitePlus |
| S11 | WSGSEsPAENM | TEA | PhosphoSitePlus |
| S87 | LARRKsRDFHS | HPRD | |
| S102 | LARRKsRDFHS | TEA | PhosphoSitePlus |
| Y263 | DIRQIyDKFPE | TEA | PhosphoSitePlus |
| S20 | NMERMsDSADK | TEA | PhosphoSitePlus |
| Dephosphorylation site |
| TEAD1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355332 | I62M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355332 | I12S | COSMIC | Lymphoma | 21995386 |
| Differential expressed protein |
| TEAD1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TEAD1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | TEAD1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TEAD1_HUMAN | U627C_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TEAD1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0035329 | hippo signaling cascade | IDA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |