| UniProt/SwissProt ID: | TCP4_HUMAN |
| Description: | SUB1 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:19985] |
| Location: | chr5 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S17 | SSGSDsDSEVD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S17 | SSGSDsDSEVD | CK2a1 | RegPhos |
| S58 | KQSSSsRDDNM | HPRD; phosphoELM; RegPhos | |
| S10 | KELVSsSSSGS | CK2a1 | RegPhos |
| S19 | GSDSDsEVDKK | CK2a1-rs | RegPhos |
| S58 | KQSSSsRDDNM | PC4 | PhosphoSitePlus |
| S17 | SSGSDsDSEVD | CK2_group | phosphoELM; RegPhos |
| S56 | SSKQSsSSRDD | HPRD; phosphoELM; RegPhos | |
| S15 | SSSSGsDSDSE | CK2a1 | RegPhos |
| S19 | GSDSDsEVDKK | CK2_group | phosphoELM; RegPhos |
| S19 | GSDSDsEVDKK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S56 | SSKQSsSSRDD | PC4 | PhosphoSitePlus |
| S13 | VSSSSsGSDSD | CK2a1-rs | RegPhos |
| S12 | LVSSSsSGSDS | PhosphoSitePlus; phosphoELM; RegPhos | |
| S9 | SKELVsSSSSG | PhosphoSitePlus; RegPhos | |
| S52 | RALSSsKQSSS | PC4 | PhosphoSitePlus |
| S118 | LKEQIsDIDDA | HPRD | |
| S9 | SKELVsSSSSG | CK2a1 | RegPhos |
| S50 | TSRALsSSKQS | HPRD; phosphoELM; RegPhos | |
| S10 | KELVSsSSSGS | PhosphoSitePlus; RegPhos | |
| S50 | TSRALsSSKQS | PC4 | PhosphoSitePlus |
| S12 | LVSSSsSGSDS | CSNK2A1 | HPRD |
| S15 | SSSSGsDSDSE | CK2a1-rs | RegPhos |
| S13 | VSSSSsGSDSD | CK2_group | phosphoELM; RegPhos |
| S15 | SSSSGsDSDSE | PhosphoSitePlus; RegPhos | |
| S15 | SSSSGsDSDSE | CK2_group | phosphoELM; RegPhos |
| S13 | VSSSSsGSDSD | PhosphoSitePlus; RegPhos | |
| S17 | SSGSDsDSEVD | CK2a1-rs | RegPhos |
| S12 | LVSSSsSGSDS | CK2a1-rs | RegPhos |
| S9 | SKELVsSSSSG | CK2a1-rs | RegPhos |
| S11 | ELVSSsSSGSD | CK2_group | phosphoELM; RegPhos |
| S118 | LKEQIsDIDDA | PC4 | PhosphoSitePlus |
| S10 | KELVSsSSSGS | CSNK2A1 | HPRD |
| S9 | SKELVsSSSSG | CSNK2A1 | HPRD |
| S13 | VSSSSsGSDSD | CK2a1 | RegPhos |
| S55 | SSSKQsSSSRD | PC4 | PhosphoSitePlus |
| S10 | KELVSsSSSGS | CK2a1-rs | RegPhos |
| S11 | ELVSSsSSGSD | PhosphoSitePlus; phosphoELM; RegPhos | |
| S104 | GRKGIsLNPEQ | PC4 | PhosphoSitePlus |
| S55 | SSSKQsSSSRD | HPRD | |
| S52 | RALSSsKQSSS | HPRD; phosphoELM; RegPhos | |
| S111 | NPEQWsQLKEQ | PC4 | PhosphoSitePlus |
| S19 | GSDSDsEVDKK | CSNK2A1 | HPRD |
| S12 | LVSSSsSGSDS | CK2a1 | RegPhos |
| S51 | SRALSsSKQSS | phosphoELM | |
| S13 | VSSSSsGSDSD | CSNK2A1 | HPRD |
| S15 | SSSSGsDSDSE | CSNK2A1 | HPRD |
| S17 | SSGSDsDSEVD | CSNK2A1 | HPRD |
| S19 | GSDSDsEVDKK | CK2a1 | RegPhos |
| Dephosphorylation site |
| TCP4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TCP4_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000265073 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.31 | 18646787 |
| Hyperphosphorylation site |
| TCP4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK2_HUMAN | TCP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | TCP4_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | TCP4_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| TCP4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003697 | single-stranded DNA binding | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | IDA | biological_process |
| GO:0005667 | transcription factor complex | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0003713 | transcription coactivator activity | IDA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |