Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TCP4_HUMAN
Description:SUB1 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:19985]
Location:chr5 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S17SSGSDsDSEVDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S17SSGSDsDSEVDCK2a1RegPhos
S58KQSSSsRDDNMHPRD; phosphoELM; RegPhos
S10KELVSsSSSGSCK2a1RegPhos
S19GSDSDsEVDKKCK2a1-rsRegPhos
S58KQSSSsRDDNMPC4PhosphoSitePlus
S17SSGSDsDSEVDCK2_groupphosphoELM; RegPhos
S56SSKQSsSSRDDHPRD; phosphoELM; RegPhos
S15SSSSGsDSDSECK2a1RegPhos
S19GSDSDsEVDKKCK2_groupphosphoELM; RegPhos
S19GSDSDsEVDKKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S56SSKQSsSSRDDPC4PhosphoSitePlus
S13VSSSSsGSDSDCK2a1-rsRegPhos
S12LVSSSsSGSDSPhosphoSitePlus; phosphoELM; RegPhos
S9SKELVsSSSSGPhosphoSitePlus; RegPhos
S52RALSSsKQSSSPC4PhosphoSitePlus
S118LKEQIsDIDDAHPRD
S9SKELVsSSSSGCK2a1RegPhos
S50TSRALsSSKQSHPRD; phosphoELM; RegPhos
S10KELVSsSSSGSPhosphoSitePlus; RegPhos
S50TSRALsSSKQSPC4PhosphoSitePlus
S12LVSSSsSGSDSCSNK2A1HPRD
S15SSSSGsDSDSECK2a1-rsRegPhos
S13VSSSSsGSDSDCK2_groupphosphoELM; RegPhos
S15SSSSGsDSDSEPhosphoSitePlus; RegPhos
S15SSSSGsDSDSECK2_groupphosphoELM; RegPhos
S13VSSSSsGSDSDPhosphoSitePlus; RegPhos
S17SSGSDsDSEVDCK2a1-rsRegPhos
S12LVSSSsSGSDSCK2a1-rsRegPhos
S9SKELVsSSSSGCK2a1-rsRegPhos
S11ELVSSsSSGSDCK2_groupphosphoELM; RegPhos
S118LKEQIsDIDDAPC4PhosphoSitePlus
S10KELVSsSSSGSCSNK2A1HPRD
S9SKELVsSSSSGCSNK2A1HPRD
S13VSSSSsGSDSDCK2a1RegPhos
S55SSSKQsSSSRDPC4PhosphoSitePlus
S10KELVSsSSSGSCK2a1-rsRegPhos
S11ELVSSsSSGSDPhosphoSitePlus; phosphoELM; RegPhos
S104GRKGIsLNPEQPC4PhosphoSitePlus
S55SSSKQsSSSRDHPRD
S52RALSSsKQSSSHPRD; phosphoELM; RegPhos
S111NPEQWsQLKEQPC4PhosphoSitePlus
S19GSDSDsEVDKKCSNK2A1HPRD
S12LVSSSsSGSDSCK2a1RegPhos
S51SRALSsSKQSSphosphoELM
S13VSSSSsGSDSDCSNK2A1HPRD
S15SSSSGsDSDSECSNK2A1HPRD
S17SSGSDsDSEVDCSNK2A1HPRD
S19GSDSDsEVDKKCK2a1RegPhos

Dephosphorylation site
TCP4_HUMAN do not have dephosphorylation site.

Mutation site
TCP4_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265073Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3118646787

Hyperphosphorylation site
TCP4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK2_HUMANTCP4_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANTCP4_HUMANkinase -> substrateRegPhos
CSK21_HUMANTCP4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
TCP4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003697single-stranded DNA bindingIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process


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