Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBCD4_HUMAN
Description:TBC1 domain family, member 4 [Source:HGNC Symbol;Acc:19165]
Location:chr13 q22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S759SNESLsVGGTSPhosphoSitePlus; HPRD
S318RSRCSsVTGVQPIDPhosphoSitePlus
S609YSPGDsPPGTPPhosphoSitePlus
S644RAHTFsHPPSSPhosphoSitePlus
S370EINLIsPDTKSPIDPhosphoSitePlus
S595DSFERsNSLASPhosphoSitePlus
S570RSLTSsLENIFPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S314QQEFRsRCSSVPIDPhosphoSitePlus
T356SEKNRtMLFQVPIDPhosphoSitePlus
S344HASAPsHVQPSHPRD; phosphoELM; RegPhos
T642RRRAHtFSHPPAKT_groupRegPhos
T642RRRAHtFSHPPPKB_groupphosphoELM
S678SSEQCsNLSSVphosphoELM
T642RRRAHtFSHPPAKT1(PKBRegPhos
S317FRSRCsSVTGVPIDPhosphoSitePlus
S673LLRQSsSEQCSphosphoELM
S750GRKRTsSTCSNPhosphoSitePlus; HPRD; phosphoELM
S318RSRCSsVTGVQphosphoELM; RegPhos
S341RRRHAsAPSHVAKT1(PKBRegPhos
S485IQRHLsSLTDNPhosphoSitePlus
S588RGRLGsVDSFEAKT1(PKBRegPhos
T320RCSSVtGVQRRPIDPhosphoSitePlus
T766GGTSVtPRRISPhosphoSitePlus; HPRD
S787SPMNKsPSAMQPhosphoSitePlus
S551ENATSsGRFKLPhosphoSitePlus; phosphoELM
S704LHTSFsAPSFTPhosphoSitePlus
T568AKRSLtSSLENPhosphoSitePlus; HPRD; phosphoELM
T752KRTSStCSNESPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S351VQPSDsEKNRTPIDPhosphoSitePlus
S66EIRRRsQKPEAPhosphoSitePlus
S751RKRTSsTCSNEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S591LGSVDsFERSNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S318RSRCSsVTGVQAKT1(PKBRegPhos
S751RKRTSsTCSNEAKT1(PKBRegPhos
S569KRSLTsSLENIPhosphoSitePlus; HPRD
S621ASPPSsAWQTFPhosphoSitePlus
S304RILEDsGFDEQPhosphoSitePlus
S570RSLTSsLENIFAKT1(PKBRegPhos
T749EGRKRtSSTCSPhosphoSitePlus; HPRD
Y1191LQESSySCEDSPhosphoSitePlus
S757TCSNEsLSVGGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S285LPAGAsQPALTPhosphoSitePlus
S617GTPPAsPPSSAPhosphoSitePlus
S672PLLRQsSSEQCphosphoELM
S566NKAKRsLTSSLPhosphoSitePlus; HPRD; phosphoELM
T763LSVGGtSVTPRPhosphoSitePlus
S649SHPPSsTKRKLPhosphoSitePlus
S666AQGVRsPLLRQPhosphoSitePlus; HPRD; phosphoELM
S344HASAPsHVQPSPIDPhosphoSitePlus
T642RRRAHtFSHPPPhosphoSitePlus; phosphoELM
T274EEADGtDTHLGPhosphoSitePlus
S648FSHPPsSTKRKPhosphoSitePlus
S633EEDSDsPQFRRPhosphoSitePlus
S341RRRHAsAPSHVPIDPhosphoSitePlus
S597FERSNsLASEKPhosphoSitePlus
S754TSSTCsNESLSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S262VVVPGsPGDCLPhosphoSitePlus
S588RGRLGsVDSFEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T613DSPPGtPPASPPhosphoSitePlus
S341RRRHAsAPSHVHPRD; phosphoELM; RegPhos
S349SHVQPsDSEKNPIDPhosphoSitePlus
S600SNSLAsEKDYSPhosphoSitePlus

Dephosphorylation site
TBCD4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366863I904MCOSMICHead and Neck Cancer21798893
ENSP00000366863S787ACOSMICOvarian Cancer21720365
ENSP00000366863R363QCOSMICMelanoma21499247
ENSP00000366863L994VCOSMICOvarian Cancer21720365
ENSP00000366863P1086LCOSMICOvarian Cancer21720365
ENSP00000366863A1223TCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000366863Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S588RMRGRLGsVDSFERStype 2 diabetes20938636PhosphoSitePlus
S318PIDEFRSRCSsVTGVQRRtype 2 diabetes20938636PhosphoSitePlus
S751EGRKRTSsTCSNESLtype 2 diabetes20938636PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTBCD4_HUMANkinase -> substrateRegPhos
AKT1_HUMANTBCD4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
TBCD4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0032313regulation of Rab GTPase activityIEAbiological_process
GO:0016192vesicle-mediated transportIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005097Rab GTPase activator activityIEAmolecular_function


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