Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TAOK3_HUMAN
Description:TAO kinase 3 [Source:HGNC Symbol;Acc:18133]
Location:chr12 q24.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T573NEDHStPKKEKPhosphoSitePlus
T316ILFQEtRNGPLPhosphoSitePlus
S331EDEEDsEHGTSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y429SQALHyRNRERPhosphoSitePlus
Y103WLVMEyCLGSAPkinasePhosphoSitePlus
S359SVSTGsQSSSVPhosphoSitePlus
T181NSFVGtPYWMASLKHPRD; RegPhos
T181NSFVGtPYWMAPkinasePhosphoSitePlus
S346MDSLGsNHSIPRegPhos
S572MNEDHsTPKKEHPRD
T437RERFAtIKSASPhosphoSitePlus
S442TIKSAsLVTRQPhosphoSitePlus; HPRD; phosphoELM
Y183FVGTPyWMAPESLKHPRD; RegPhos
Y305LDNLQyRKMKKPhosphoSitePlus
Y897FPKEDyR____PhosphoSitePlus
S349LGSNHsIPSMSRegPhos
S324GPLNEsQEDEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S551TTFLEsQKKQYPhosphoSitePlus
S177ASPANsFVGTPPkinasePhosphoSitePlus
S782NEMMAsQALRLPhosphoSitePlus

Dephosphorylation site
TAOK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376317P20TGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000416374S356RCOSMICOvarian Cancer21720365
ENSP00000376317L742FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000376317S392YGreenman2007Lung Cancer17344846, 18428421
ENSP00000416374V626MCOSMICSkin Cancer21984974
ENSP00000376317S392YHPISmall cell lung carcinoma17344846
ENSP00000416374A125SCOSMICGastric Cancer21097718

Differential expressed protein
TAOK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TAOK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTAOK3_HUMANkinase -> substrateRegPhos
SLK_HUMANTAOK3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043507positive regulation of JUN kinase activityIMPbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006281DNA repairIEAbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0046330positive regulation of JNK cascadeIMPbiological_process
GO:0046329negative regulation of JNK cascadeIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0016740transferase activityIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0031572G2/M transition DNA damage checkpointIMPbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0032874positive regulation of stress-activated MAPK cascaIMPbiological_process
GO:0006469negative regulation of protein kinase activityTASbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000165MAPK cascadeIMPbiological_process
GO:0004860protein kinase inhibitor activityTASmolecular_function


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