| UniProt/SwissProt ID: | TAOK3_HUMAN |
| Description: | TAO kinase 3 [Source:HGNC Symbol;Acc:18133] |
| Location: | chr12 q24.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T573 | NEDHStPKKEK | PhosphoSitePlus | |
| T316 | ILFQEtRNGPL | PhosphoSitePlus | |
| S331 | EDEEDsEHGTS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y429 | SQALHyRNRER | PhosphoSitePlus | |
| Y103 | WLVMEyCLGSA | Pkinase | PhosphoSitePlus |
| S359 | SVSTGsQSSSV | PhosphoSitePlus | |
| T181 | NSFVGtPYWMA | SLK | HPRD; RegPhos |
| T181 | NSFVGtPYWMA | Pkinase | PhosphoSitePlus |
| S346 | MDSLGsNHSIP | RegPhos | |
| S572 | MNEDHsTPKKE | HPRD | |
| T437 | RERFAtIKSAS | PhosphoSitePlus | |
| S442 | TIKSAsLVTRQ | PhosphoSitePlus; HPRD; phosphoELM | |
| Y183 | FVGTPyWMAPE | SLK | HPRD; RegPhos |
| Y305 | LDNLQyRKMKK | PhosphoSitePlus | |
| Y897 | FPKEDyR____ | PhosphoSitePlus | |
| S349 | LGSNHsIPSMS | RegPhos | |
| S324 | GPLNEsQEDEE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S551 | TTFLEsQKKQY | PhosphoSitePlus | |
| S177 | ASPANsFVGTP | Pkinase | PhosphoSitePlus |
| S782 | NEMMAsQALRL | PhosphoSitePlus | |
| Dephosphorylation site |
| TAOK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376317 | P20T | Greenman2007, HPI | Lung Cancer | 17344846, 18428421 | ENSP00000416374 | S356R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000376317 | L742F | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000376317 | S392Y | Greenman2007 | Lung Cancer | 17344846, 18428421 | ENSP00000416374 | V626M | COSMIC | Skin Cancer | 21984974 | ENSP00000376317 | S392Y | HPI | Small cell lung carcinoma | 17344846 | ENSP00000416374 | A125S | COSMIC | Gastric Cancer | 21097718 |
| Differential expressed protein |
| TAOK3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TAOK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | TAOK3_HUMAN | kinase -> substrate | RegPhos |
| SLK_HUMAN | TAOK3_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043507 | positive regulation of JUN kinase activity | IMP | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0046330 | positive regulation of JNK cascade | IMP | biological_process |
| GO:0046329 | negative regulation of JNK cascade | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0016740 | transferase activity | IDA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0031572 | G2/M transition DNA damage checkpoint | IMP | biological_process |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0032874 | positive regulation of stress-activated MAPK casca | IMP | biological_process |
| GO:0006469 | negative regulation of protein kinase activity | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000165 | MAPK cascade | IMP | biological_process |
| GO:0004860 | protein kinase inhibitor activity | TAS | molecular_function |