| UniProt/SwissProt ID: | TAOK2_HUMAN |
| Description: | TAO kinase 2 [Source:HGNC Symbol;Acc:16835] |
| Location: | chr16 p11.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y426 | GSDNLyDDPYQ | PhosphoSitePlus | |
| Y430 | LYDDPyQPEIT | PhosphoSitePlus | |
| S486 | EHEQDsALREQ | PhosphoSitePlus; HPRD | |
| Y309 | LDNLQyRKMKK | PhosphoSitePlus | |
| S452 | PTSTTsSARRR | PhosphoSitePlus | |
| S656 | LLARHsLDQDL | PhosphoSitePlus | |
| S603 | LQENPsTPKRE | PhosphoSitePlus | |
| Y338 | EEAEPyMHRAG | PhosphoSitePlus | |
| S181 | MAPANsFVGTP | Pkinase | PhosphoSitePlus |
| S825 | ESGAPsPSPQK | PhosphoSitePlus; HPRD | |
| S9 | GGRAGsLKDPD | PhosphoSitePlus; HPRD | |
| S473 | TIRTAsLVSRQ | PhosphoSitePlus; HPRD | |
| Y107 | WLVMEyCLGSA | Pkinase | PhosphoSitePlus |
| S29 | PEKLFsDLREI | Pkinase | PhosphoSitePlus |
| T344 | MHRAGtLTSLE | PhosphoSitePlus | |
| S38 | EIGHGsFGAVY | Pkinase | PhosphoSitePlus |
| S777 | EQQPCsPGQEA | PhosphoSitePlus; HPRD | |
| T468 | RDHFAtIRTAS | PhosphoSitePlus | |
| S437 | PEITPsPLQPP | PhosphoSitePlus; HPRD | |
| S347 | AGTLTsLESSH | PhosphoSitePlus | |
| Y43 | SFGAVyFARDV | Pkinase | PhosphoSitePlus |
| T604 | QENPStPKREK | PhosphoSitePlus | |
| S827 | GAPSPsPQKHG | PhosphoSitePlus; HPRD | |
| Y61 | IKKMSySGKQS | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| TAOK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TAOK2_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000310094 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| TAOK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TAOK2_HUMAN | ELK1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0032874 | positive regulation of stress-activated MAPK casca | IMP | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0030036 | actin cytoskeleton organization | IDA | biological_process |
| GO:0006612 | protein targeting to membrane | NAS | biological_process |
| GO:0006950 | response to stress | IDA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0051403 | stress-activated MAPK cascade | IDA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0031434 | mitogen-activated protein kinase kinase binding | IPI | molecular_function |
| GO:0046330 | positive regulation of JNK cascade | IDA | biological_process |
| GO:0048041 | focal adhesion assembly | IDA | biological_process |
| GO:0006915 | apoptotic process | NAS | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0000186 | activation of MAPKK activity | IDA | biological_process |
| GO:0016477 | cell migration | NAS | biological_process |
| GO:0008360 | regulation of cell shape | IDA | biological_process |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0030425 | dendrite | IEA | cellular_component |
| GO:0031572 | G2/M transition DNA damage checkpoint | IMP | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0001558 | regulation of cell growth | NAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |