| UniProt/SwissProt ID: | TAOK1_HUMAN |
| Description: | TAO kinase 1 [Source:HGNC Symbol;Acc:29259] |
| Location: | chr17 q11.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y309 | LDNLQyRKMKK | PhosphoSitePlus | |
| S987 | MSRSTsVTSQI | PhosphoSitePlus | |
| T185 | NSFVGtPYWMA | Pkinase | PhosphoSitePlus |
| Y43 | SFGAVyFARDV | Pkinase | PhosphoSitePlus |
| S66 | YSGKQsTEKWQ | Pkinase | PhosphoSitePlus |
| T669 | FRHLNtIQKMR | PhosphoSitePlus | |
| T734 | TCKIQtRQYKA | PhosphoSitePlus | |
| Y107 | WLVMEyCLGSA | Pkinase | PhosphoSitePlus |
| S9 | TNRAGsLKDPE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S714 | RQQPKsLKSKE | PhosphoSitePlus | |
| S181 | ASPANsFVGTP | Pkinase | PhosphoSitePlus |
| S421 | ASDPQsPPQVS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S426 | SPPQVsRHKSH | PhosphoSitePlus | |
| S445 | TIRTAsLVTRQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T576 | NENQStPKKEK | PhosphoSitePlus | |
| S417 | PRTRAsDPQSP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y406 | PEEENyREEGD | PhosphoSitePlus | |
| Y610 | RRQRQyLELEC | PhosphoSitePlus | |
| T480 | QKQLMtLENKL | PhosphoSitePlus | |
| T643 | LNKRQtQKDLE | PhosphoSitePlus | |
| T440 | REHFAtIRTAS | PhosphoSitePlus | |
| S965 | MGVRNsPQALR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S959 | VPRGSsMGVRN | HPRD; SysPTM | |
| S958 | GVPRGsSMGVR | HPRD; SysPTM | |
| T1001 | SHMSYt_____ | PhosphoSitePlus | |
| T785 | NEMLStQALRL | PhosphoSitePlus | |
| S554 | NSFLEsQKREY | PhosphoSitePlus | |
| T502 | DKDLEtQRNNF | PhosphoSitePlus | |
| Y432 | RHKSHyRNREH | PhosphoSitePlus | |
| S990 | STSVTsQISNG | PhosphoSitePlus | |
| Dephosphorylation site |
| TAOK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261716 | R860C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000261716 | N639S | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000261716 | E580K | COSMIC | Melanoma | 21499247 | ENSP00000261716 | R606C | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| TAOK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TAOK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TAOK1_HUMAN | MARK1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046330 | positive regulation of JNK cascade | IDA | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0031572 | G2/M transition DNA damage checkpoint | IMP | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0016740 | transferase activity | NAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0032874 | positive regulation of stress-activated MAPK casca | IMP | biological_process |
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0006468 | protein phosphorylation | NAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006915 | apoptotic process | IDA | biological_process |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | ISS | molecular_function |
| GO:0051493 | regulation of cytoskeleton organization | ISS | biological_process |
| GO:0016301 | kinase activity | NAS | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |