Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYGP1_HUMAN
Description:synaptic Ras GTPase activating protein 1 [Source:HGNC Symbol;Acc:11497]
Location:chr6 p21.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S780RGLNSsMDMARHPRD
S1261DSQIKsIIGRLDUF3498PhosphoSitePlus
Y1183YKLKEySKSMDDUF3498PhosphoSitePlus
S766RDLNSsIDLQSHPRD
S771SIDLQsFMARGHPRD
T913QMGVTtDGVPADUF3498PhosphoSitePlus
S1138ITKQHsQTPSTCAMK2AHPRD
S1190KSMDEsRLDRVDUF3498PhosphoSitePlus
T1077KSQQLtVSAAQCAMK2AHPRD
S1132GGLKPsITKQHDUF3498PhosphoSitePlus
S779ARGLNsSMDMAHPRD
S1114LSKEGsIGGSGDUF3498PhosphoSitePlus
Y682SSFEGyIDLGRPhosphoSitePlus
S1073LQRGKsQQLTVCAMK2AHPRD
S449KEEVAsALVHIPhosphoSitePlus
S842VNKSVsMLDLQDUF3498PhosphoSitePlus
S1079QQLTVsAAQKPHPRD
S1184KLKEYsKSMDEDUF3498PhosphoSitePlus
S907AGMRLsQMGVTDUF3498PhosphoSitePlus
T912SQMGVtTDGVPDUF3498PhosphoSitePlus
S1186KEYSKsMDESRDUF3498PhosphoSitePlus
S840LSVNKsVSMLDDUF3498PhosphoSitePlus

Dephosphorylation site
SYGP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000293748G380ECOSMICCentral Nervous System Neoplasms
ENSP00000293748R1222WBIOMARTBreast Cancer21930507, 21930502
ENSP00000403636G380EBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000293748S1088ICOSMICOvarian Cancer21720365
ENSP00000293748K793*COSMICOvarian Cancer21720365
ENSP00000293748I1039TCOSMICOvarian Cancer21720365
ENSP00000293748D974NCOSMICOvarian Cancer21720365
ENSP00000293748G355RCOSMICOvarian Cancer21720365
ENSP00000403636R1222WBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
SYGP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SYGP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2A_HUMANSYGP1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
SYGP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005099Ras GTPase activator activityIBAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0016358dendrite developmentIEAbiological_process
GO:0005737cytoplasmIBAcellular_component
GO:0050803regulation of synapse structure and activityIEAbiological_process
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0005097Rab GTPase activator activityIEAmolecular_function
GO:0043408regulation of MAPK cascadeIEAbiological_process
GO:0005096GTPase activator activityIEAmolecular_function
GO:0043113receptor clusteringIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0050771negative regulation of axonogenesisIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0007389pattern specification processIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0032320positive regulation of Ras GTPase activityIBAbiological_process
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0032851positive regulation of Rab GTPase activityIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0031235intrinsic to internal side of plasma membraneIBAcellular_component
GO:0016020membraneIEAcellular_component
GO:0048167regulation of synaptic plasticityISSbiological_process
GO:0043198dendritic shaftIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0046580negative regulation of Ras protein signal transducISSbiological_process