Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STK10_HUMAN
Description:serine/threonine kinase 10 [Source:HGNC Symbol;Acc:11388]
Location:chr5 q35.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S454QSRPNsSALETPhosphoSitePlus; HPRD; phosphoELM
T459SSALEtLGGEKPhosphoSitePlus
S13RILRLsTFEKRPhosphoSitePlus; HPRD; phosphoELM
T195DSFIGtPYWMAPkinasePhosphoSitePlus
S549TSKIIsEDEKKPhosphoSitePlus
T391RSLQTtSPPVVPhosphoSitePlus; HPRD; phosphoELM
S438QGGDLsPAANRPhosphoSitePlus; HPRD; phosphoELM
S951ECPNPsTPSKAPhosphoSitePlus; HPRD
T390DRSLQtTSPPVHPRD
S844KIKQFsQQEEKPhosphoSitePlus; HPRD
S455SRPNSsALETLPhosphoSitePlus; phosphoELM
S514NKEMGsLSIKDPhosphoSitePlus; HPRD
S387PSGDRsLQTTSHPRD
S448RSQKAsQSRPNHPRD; phosphoELM
S450QKASQsRPNSSPhosphoSitePlus; HPRD; phosphoELM
T530KTLKRtRKFVVPhosphoSitePlus
T185AKNLKtLQKRDPkinasePhosphoSitePlus
T208VVMCEtMKDTPPkinasePhosphoSitePlus
T185AKNLKtLQKRDHPRD; phosphoELM
S485PSKRDsDCSSLPhosphoSitePlus
S495LCTSEsMDYGTPhosphoSitePlus
S417KSRPVsMDARIPhosphoSitePlus
Y197FIGTPyWMAPEPkinasePhosphoSitePlus
S392SLQTTsPPVVAPhosphoSitePlus; HPRD
S455SRPNSsALETLSTK10HPRD
S444PAANRsQKASQPhosphoSitePlus
S179ADFGVsAKNLKPkinasePhosphoSitePlus
S679QQRKEsMKQKMPhosphoSitePlus
T166GNVLMtLEGDIPkinasePhosphoSitePlus
S20FEKRKsREYEHPhosphoSitePlus; HPRD
T952CPNPStPSKAAPhosphoSitePlus; HPRD; phosphoELM
S545VSITTsKIISEPhosphoSitePlus
S954NPSTPsKAAKFPhosphoSitePlus
S191LQKRDsFIGTPHPRD; phosphoELM
T14ILRLStFEKRKPhosphoSitePlus; HPRD
S191LQKRDsFIGTPPkinasePhosphoSitePlus

Dephosphorylation site
STK10_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000176763K277EGreenman2007, HPITesticular Cancer16175573, 17344846, 18428421, 16175573, 17344846, 16175573 17344846
ENSP00000176763N442SBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000176763Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059

Hyperphosphorylation site
STK10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK10_HUMANSTK10_HUMANkinase -> substrateHPRD
STK10_HUMANPLK1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
STK10_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042801polo kinase kinase activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:2000401regulation of lymphocyte migrationIMPbiological_process
GO:0071593lymphocyte aggregationIEAbiological_process
GO:0071593lymphocyte aggregationISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:2000401regulation of lymphocyte migrationIEAbiological_process