Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STEA3_HUMAN
Description:STEAP family member 3, metalloreductase [Source:HGNC Symbol;Acc:24592]
Location:chr2 q14.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S27LHLVDsDSSLAHPRD
Y331RRAHRyDLVNLFerric_reductPhosphoSitePlus
Y249DVLQPyVQESQHPRD
S19LVDSDsSLAKVPhosphoSitePlus; HPRD
S243PYVQEsQNKFFPhosphoSitePlus; HPRD
T141LFPTCtVVKAFF420_oxidoredPhosphoSitePlus
S479GWEREsTIKFTHPRD
S17LHLVDsDSSLAPhosphoSitePlus; HPRD; phosphoELM
S20VDSDSsLAKVPPhosphoSitePlus; HPRD
Y227LFVCFyAYNFVTMPhosphoSitePlus
S469GWEREsTIKFTPhosphoSitePlus; HPRD
S42GDFARsLATRLF420_oxidoredPhosphoSitePlus
T470WEREStIKFTLPhosphoSitePlus
S30VDSDSsLAKVPHPRD
S29LVDSDsSLAKVHPRD
Y239DVLQPyVQESQPhosphoSitePlus; HPRD
S253PYVQEsQNKFFHPRD

Dephosphorylation site
STEA3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376818V441ICOSMICCentral Nervous System Neoplasms18772396
ENSP00000376818E352KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000376818D18NCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000396214Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
STEA3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMANSTEA3_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006879cellular iron ion homeostasisTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0010008endosome membraneTAScellular_component
GO:0005771multivesicular bodyIDAcellular_component
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0006826iron ion transportIEAbiological_process
GO:0000293ferric-chelate reductase activityIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005768endosomeIEAcellular_component
GO:0033572transferrin transportTASbiological_process
GO:0009306protein secretionIDAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0055114oxidation-reduction processIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function


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