| UniProt/SwissProt ID: | STEA3_HUMAN |
| Description: | STEAP family member 3, metalloreductase [Source:HGNC Symbol;Acc:24592] |
| Location: | chr2 q14.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S27 | LHLVDsDSSLA | HPRD | |
| Y331 | RRAHRyDLVNL | Ferric_reduct | PhosphoSitePlus |
| Y249 | DVLQPyVQESQ | HPRD | |
| S19 | LVDSDsSLAKV | PhosphoSitePlus; HPRD | |
| S243 | PYVQEsQNKFF | PhosphoSitePlus; HPRD | |
| T141 | LFPTCtVVKAF | F420_oxidored | PhosphoSitePlus |
| S479 | GWEREsTIKFT | HPRD | |
| S17 | LHLVDsDSSLA | PhosphoSitePlus; HPRD; phosphoELM | |
| S20 | VDSDSsLAKVP | PhosphoSitePlus; HPRD | |
| Y227 | LFVCFyAYNFV | TM | PhosphoSitePlus |
| S469 | GWEREsTIKFT | PhosphoSitePlus; HPRD | |
| S42 | GDFARsLATRL | F420_oxidored | PhosphoSitePlus |
| T470 | WEREStIKFTL | PhosphoSitePlus | |
| S30 | VDSDSsLAKVP | HPRD | |
| S29 | LVDSDsSLAKV | HPRD | |
| Y239 | DVLQPyVQESQ | PhosphoSitePlus; HPRD | |
| S253 | PYVQEsQNKFF | HPRD | |
| Dephosphorylation site |
| STEA3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376818 | V441I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000376818 | E352K | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000376818 | D18N | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000396214 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| STEA3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | STEA3_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04115 | p53 signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006879 | cellular iron ion homeostasis | TAS | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0010008 | endosome membrane | TAS | cellular_component |
| GO:0005771 | multivesicular body | IDA | cellular_component |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0006826 | iron ion transport | IEA | biological_process |
| GO:0000293 | ferric-chelate reductase activity | IEA | molecular_function |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005768 | endosome | IEA | cellular_component |
| GO:0033572 | transferrin transport | TAS | biological_process |
| GO:0009306 | protein secretion | IDA | biological_process |
| GO:0006917 | induction of apoptosis | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |