Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STAM1_HUMAN
Description:signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Source:HGNC Symbol;Acc:11357]
Location:chr10 p12.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S202LYPSTsSLLTNPhosphoSitePlus
Y198TLSTLyPSTSSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y381NEDPMySMYAKPhosphoSitePlus; HPRD; SysPTM
Y384PMYSMyAKLQNPhosphoSitePlus
S147FPAIGsQAAEQHPRD
S156EQAKAsPALVAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S200STLYPsTSSLLPhosphoSitePlus
Y371EALSLyTKLMNGATPhosphoSitePlus
S382EDPMYsMYAKLPhosphoSitePlus
S203YPSTSsLLTNHPhosphoSitePlus
T372ALSLYtKLMNEGATPhosphoSitePlus
T196STTLStLYPSTPhosphoSitePlus
T206TSSLLtNHQHEPhosphoSitePlus

Dephosphorylation site
STAM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366746E118GCOSMICOvarian Cancer21720365
ENSP00000366746G212DHPIColorectal Cancer16959974
ENSP00000366746S49CBIOMARTBreast Cancer21930507, 21930502
ENSP00000366746E118GTCGAOvarian Cancer21720365, 18772890
ENSP00000366746E366KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000366746G212DSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000366746E225KCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000366746Esophageal CancerNormal vs. CancertissueDown0.4619142970

Hyperphosphorylation site
STAM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK2_HUMANSTAM1_HUMANkinase -> substrateNetPath
JAK3_HUMANSTAM1_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0016197endosomal transportTASbiological_process
GO:0016044cellular membrane organizationTASbiological_process
GO:0031901early endosome membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006886intracellular protein transportIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0042059negative regulation of epidermal growth factor recTASbiological_process


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