Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPY2_HUMAN
Description:sprouty homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:11270]
Location:chr13 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y176LGLHAyRCEDCPhosphoSitePlus
S296CRCKNsNTVCCPhosphoSitePlus
Y269PCLWCyLPAKGSproutyPhosphoSitePlus
S139RLLGSsFSSGPPhosphoSitePlus; HPRD; SysPTM
Y227VKGLFyHCSNDSproutyPhosphoSitePlus
Y55RNTNEyTEGPTPhosphoSitePlus; phosphoELM
S138QRLLGsSFSSGPhosphoSitePlus
S142GSSFSsGPVADPhosphoSitePlus
S197PRPLPsDWICDSproutyPhosphoSitePlus
S167ELKPLsKEDLGPhosphoSitePlus
T75APRPStQHKHEPhosphoSitePlus
S7EARAQsGNGSQPhosphoSitePlus
Y191CKECTyPRPLPSproutyPhosphoSitePlus
T56NTNEYtEGPTVPhosphoSitePlus
S121SGSRSsTRTSTPhosphoSitePlus
S112LSRSIsTVSSGPhosphoSitePlus
S11QSGNGsQPLLQPhosphoSitePlus
Y227VKGLFyHCSNDphosphoELM; RegPhos
T298CKNSNtVCCKVPhosphoSitePlus
S141LGSSFsSGPVAPhosphoSitePlus
S156RVQPKsELKPGPhosphoSitePlus
T75APRPStQHKHEDYRK1AphosphoELM
S115SISTVsSGSRSPhosphoSitePlus
T17QPLLQtPRDGGPhosphoSitePlus
Y283LCQGCyDRVNRSproutyPhosphoSitePlus
T190KCKECtYPRPLSproutyPhosphoSitePlus
T305CCKVPtVPPRNPhosphoSitePlus
Y55RNTNEyTEGPTSRCphosphoELM
S116ISTVSsGSRSSPhosphoSitePlus
S118TVSSGsRSSTRPhosphoSitePlus
Y55RNTNEyTEGPTSrcRegPhos
S42QVHVLsLDQIRPhosphoSitePlus

Dephosphorylation site
SPY2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366308C218RCOSMICLung Cancer20668451
ENSP00000366306V62ICOSMICOvarian Cancer21720365
ENSP00000366308V62ICOSMICOvarian Cancer21720365
ENSP00000366306C218RCOSMICLung Cancer20668451
ENSP00000439027C218RCOSMICLung Cancer20668451
ENSP00000439027V62ICOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000366306Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
SPY2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSPY2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032587ruffle membraneIEAcellular_component
GO:0007605sensory perception of soundIEAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIMPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0005874microtubuleIEAcellular_component
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0071902positive regulation of protein serine/threonine kiIMPbiological_process
GO:0010801negative regulation of peptidyl-threonine phosphorIDAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0043539protein serine/threonine kinase activator activityIMPmolecular_function
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0034261negative regulation of Ras GTPase activityIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0060437lung growthIEAbiological_process
GO:0009966regulation of signal transductionIEAbiological_process
GO:0051387negative regulation of nerve growth factor receptoIEAbiological_process
GO:0060541respiratory system developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0030291protein serine/threonine kinase inhibitor activityICmolecular_function
GO:0060425lung morphogenesisIEAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0040037negative regulation of fibroblast growth factor reIEAbiological_process
GO:0046580negative regulation of Ras protein signal transducIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process


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