| UniProt/SwissProt ID: | SPT5H_HUMAN |
| Description: | suppressor of Ty 5 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:11469] |
| Location: | chr19 q13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S773 | TPMYGsQTPMY | CTD | PhosphoSitePlus |
| T762 | RPGGMtSTYGR | CTD | PhosphoSitePlus |
| T1036 | EPITPtKNNKV | PhosphoSitePlus | |
| Y771 | GRTPMyGSQTP | CTD | PhosphoSitePlus |
| T775 | MYGSQtPMYGS | CTD | PhosphoSitePlus |
| Y802 | SRTPHyGSQTP | CTD | PhosphoSitePlus |
| Y86 | DVDDEyEDEDQ | Spt5_N | PhosphoSitePlus |
| S812 | PLHDGsRTPAQ | CTD | PhosphoSitePlus |
| T784 | GSGSRtPMYGS | CTD | PhosphoSitePlus |
| T709 | ELIGQtVRISQ | RegPhos | |
| S797 | PLQDGsRTPHY | CTD | PhosphoSitePlus |
| Y230 | IYVEAyKQTHV | Spt5-NGN | PhosphoSitePlus |
| T768 | STYGRtPMYGS | CTD | PhosphoSitePlus |
| T764 | GGMTStYGRTP | CTD | PhosphoSitePlus |
| S36 | RSAAGsEKEEE | PhosphoSitePlus | |
| Y778 | SQTPMyGSGSR | CTD | PhosphoSitePlus |
| T208 | YQFTDtPLQIK | Spt5-NGN | PhosphoSitePlus |
| S671 | SPRISsPMHPS | PhosphoSitePlus; phosphoELM | |
| Y141 | ELGEYyMKKYA | Spt5_N | PhosphoSitePlus |
| S804 | TPHYGsQTPLH | CTD | PhosphoSitePlus |
| S789 | TPMYGsQTPLQ | CTD | PhosphoSitePlus |
| Y140 | EELGEyYMKKY | Spt5_N | PhosphoSitePlus |
| Y787 | SRTPMyGSQTP | CTD | PhosphoSitePlus |
| Y765 | GMTSTyGRTPM | CTD | PhosphoSitePlus |
| T1034 | HLEPItPTKNN | PhosphoSitePlus; phosphoELM; RegPhos; SysPTM | |
| S19 | DSERSsDGEEA | PhosphoSitePlus; phosphoELM; RegPhos | |
| S32 | DEERRsAAGSE | PhosphoSitePlus | |
| T799 | QDGSRtPHYGS | CTD | PhosphoSitePlus |
| T806 | HYGSQtPLHDG | CTD | PhosphoSitePlus |
| Y717 | ISQGPyKGYIG | RegPhos | |
| Y295 | IAQVDyVEPSQ | KOW | PhosphoSitePlus |
| S666 | GFAPMsPRISS | PhosphoSitePlus; phosphoELM; RegPhos; SysPTM | |
| T814 | HDGSRtPAQSG | CTD | PhosphoSitePlus |
| T791 | MYGSQtPLQDG | CTD | PhosphoSitePlus |
| S375 | GFLFKsFAMSA | PhosphoSitePlus | |
| T784 | GSGSRtPMYGS | CDK9 | RegPhos |
| T775 | MYGSQtPMYGS | CDK9 | RegPhos |
| Dephosphorylation site |
| SPT5H_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000352117 | R416W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000404029 | R416W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000352117 | G819W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000352117 | E362Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000352117 | E29* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352117 | E362Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000404029 | E362Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000352117 | R416W | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| SPT5H_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SPT5H_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | SPT5H_HUMAN | kinase -> substrate | RegPhos |
| CDK9_HUMAN | SPT5H_HUMAN | kinase -> substrate | RegPhos |
| MK09_HUMAN | SPT5H_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SPT5H_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0010033 | response to organic substance | TAS | biological_process |
| GO:0032786 | positive regulation of DNA-dependent transcription | IDA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006370 | 7-methylguanosine mRNA capping | TAS | biological_process |
| GO:0032968 | positive regulation of transcription elongation fr | IEA | biological_process |
| GO:0006338 | chromatin remodeling | NAS | biological_process |
| GO:0050434 | positive regulation of viral transcription | TAS | biological_process |
| GO:0032784 | regulation of DNA-dependent transcription, elongat | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032785 | negative regulation of DNA-dependent transcription | IDA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0032044 | DSIF complex | IDA | cellular_component |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0046982 | protein heterodimerization activity | IPI | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007049 | cell cycle | NAS | biological_process |
| GO:0016239 | positive regulation of macroautophagy | IMP | biological_process |
| GO:0045090 | retroviral genome replication | NAS | biological_process |
| GO:0006368 | transcription elongation from RNA polymerase II pr | IDA | biological_process |
| GO:0006354 | DNA-dependent transcription, elongation | IDA | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |