Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPT5H_HUMAN
Description:suppressor of Ty 5 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:11469]
Location:chr19 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S773TPMYGsQTPMYCTDPhosphoSitePlus
T762RPGGMtSTYGRCTDPhosphoSitePlus
T1036EPITPtKNNKVPhosphoSitePlus
Y771GRTPMyGSQTPCTDPhosphoSitePlus
T775MYGSQtPMYGSCTDPhosphoSitePlus
Y802SRTPHyGSQTPCTDPhosphoSitePlus
Y86DVDDEyEDEDQSpt5_NPhosphoSitePlus
S812PLHDGsRTPAQCTDPhosphoSitePlus
T784GSGSRtPMYGSCTDPhosphoSitePlus
T709ELIGQtVRISQRegPhos
S797PLQDGsRTPHYCTDPhosphoSitePlus
Y230IYVEAyKQTHVSpt5-NGNPhosphoSitePlus
T768STYGRtPMYGSCTDPhosphoSitePlus
T764GGMTStYGRTPCTDPhosphoSitePlus
S36RSAAGsEKEEEPhosphoSitePlus
Y778SQTPMyGSGSRCTDPhosphoSitePlus
T208YQFTDtPLQIKSpt5-NGNPhosphoSitePlus
S671SPRISsPMHPSPhosphoSitePlus; phosphoELM
Y141ELGEYyMKKYASpt5_NPhosphoSitePlus
S804TPHYGsQTPLHCTDPhosphoSitePlus
S789TPMYGsQTPLQCTDPhosphoSitePlus
Y140EELGEyYMKKYSpt5_NPhosphoSitePlus
Y787SRTPMyGSQTPCTDPhosphoSitePlus
Y765GMTSTyGRTPMCTDPhosphoSitePlus
T1034HLEPItPTKNNPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S19DSERSsDGEEAPhosphoSitePlus; phosphoELM; RegPhos
S32DEERRsAAGSEPhosphoSitePlus
T799QDGSRtPHYGSCTDPhosphoSitePlus
T806HYGSQtPLHDGCTDPhosphoSitePlus
Y717ISQGPyKGYIGRegPhos
Y295IAQVDyVEPSQKOWPhosphoSitePlus
S666GFAPMsPRISSPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
T814HDGSRtPAQSGCTDPhosphoSitePlus
T791MYGSQtPLQDGCTDPhosphoSitePlus
S375GFLFKsFAMSAPhosphoSitePlus
T784GSGSRtPMYGSCDK9RegPhos
T775MYGSQtPMYGSCDK9RegPhos

Dephosphorylation site
SPT5H_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352117R416WCOSMICOvarian Cancer21720365
ENSP00000404029R416WTCGAOvarian Cancer21720365, 18772890
ENSP00000352117G819WCOSMICHead and Neck Cancer21798893
ENSP00000352117E362QTCGAOvarian Cancer21720365, 18772890
ENSP00000352117E29*COSMICOvarian Cancer21720365
ENSP00000352117E362QCOSMICOvarian Cancer21720365
ENSP00000404029E362QTCGAOvarian Cancer21720365, 18772890
ENSP00000352117R416WTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
SPT5H_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SPT5H_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSPT5H_HUMANkinase -> substrateRegPhos
CDK9_HUMANSPT5H_HUMANkinase -> substrateRegPhos
MK09_HUMANSPT5H_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SPT5H_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019899enzyme bindingIPImolecular_function
GO:0010033response to organic substanceTASbiological_process
GO:0032786positive regulation of DNA-dependent transcriptionIDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0032968positive regulation of transcription elongation frIEAbiological_process
GO:0006338chromatin remodelingNASbiological_process
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0032784regulation of DNA-dependent transcription, elongatIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0032785negative regulation of DNA-dependent transcriptionIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0032044DSIF complexIDAcellular_component
GO:0016032viral reproductionTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0007049cell cycleNASbiological_process
GO:0016239positive regulation of macroautophagyIMPbiological_process
GO:0045090retroviral genome replicationNASbiological_process
GO:0006368transcription elongation from RNA polymerase II prIDAbiological_process
GO:0006354DNA-dependent transcription, elongationIDAbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process


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