| UniProt/SwissProt ID: | SPEG_HUMAN |
| Description: | SPEG complex locus [Source:HGNC Symbol;Acc:16901] |
| Location: | chr2 q35 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T599 | DQFPLtRSRAI | PhosphoSitePlus | |
| S2945 | SSPGSsPRSSP | PhosphoSitePlus | |
| S2458 | MRRRLsFTLER | PhosphoSitePlus | |
| S261 | YGSAFsLYRGR | PhosphoSitePlus | |
| S2130 | LQKSSsFSQGE | PhosphoSitePlus | |
| S506 | IRRSTsREELV | PhosphoSitePlus | |
| S453 | GTPGAsQEELR | PhosphoSitePlus; phosphoELM | |
| S2045 | LPQRRsPSPGA | PhosphoSitePlus | |
| S2658 | GLYECsATNVL | I-set | PhosphoSitePlus |
| S2948 | GSSPRsSPRPE | PhosphoSitePlus | |
| T2495 | RLRRAtSEGES | PhosphoSitePlus | |
| S381 | PLSEAsGRLSA | PhosphoSitePlus | |
| S258 | SDLYGsAFSLY | PhosphoSitePlus | |
| S2521 | GATTPsAESLG | PhosphoSitePlus | |
| T449 | GAPWGtPGASQ | PhosphoSitePlus; phosphoELM | |
| S334 | AATPTsPHRRT | PhosphoSitePlus | |
| S2444 | SEGGSsARGSP | PhosphoSitePlus | |
| T2518 | AQAGAtTPSAE | PhosphoSitePlus | |
| S1172 | LEKMPsIPEEP | PhosphoSitePlus | |
| T333 | PAATPtSPHRR | PhosphoSitePlus | |
| T3254 | RAEAAtRHKVL | PhosphoSitePlus | |
| S371 | AGTAEsRPQTP | PhosphoSitePlus | |
| T375 | ESRPQtPLSEA | PhosphoSitePlus | |
| S2015 | LRRGSsAESAL | PhosphoSitePlus | |
| S2944 | VSSPGsSPRSS | PhosphoSitePlus | |
| S2014 | ELRRGsSAESA | PhosphoSitePlus | |
| S2128 | RGLQKsSSFSQ | PhosphoSitePlus | |
| S2109 | MARAAsSEAAP | PhosphoSitePlus | |
| S609 | IQECRsPVPPP | PhosphoSitePlus | |
| S2129 | GLQKSsSFSQG | PhosphoSitePlus | |
| S378 | PQTPLsEASGR | PhosphoSitePlus | |
| S2410 | LVRRLsLSLSQ | PhosphoSitePlus | |
| S2471 | SRLQRsGSSED | PhosphoSitePlus | |
| Dephosphorylation site |
| SPEG_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000311684 | E1942* | Greenman2007 | Ovarian Cancer | 17344846, 18428421 | ENSP00000311684 | R1903W | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 | ENSP00000311684 | V2742M | Greenman2007, HPI | Gastric Cancer | 17344846, 18428421 | ENSP00000311684 | E1178D | Greenman2007, HPI | Gastric Cancer | 17344846, 18428421 |
| Differential expressed protein |
| SPEG_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SPEG_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | SPEG_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SPEG_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007517 | muscle organ development | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0042692 | muscle cell differentiation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |