| UniProt/SwissProt ID: | SPAG1_HUMAN |
| Description: | sperm associated antigen 1 [Source:HGNC Symbol;Acc:11212] |
| Location: | chr8 q22.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y225 | FNSGDyEEAVM | TPR_1; MIT | PhosphoSitePlus |
| T618 | RQQGItDEKTF | PhosphoSitePlus | |
| S72 | ALAPEsRALRK | PhosphoSitePlus | |
| S423 | SPRRAsAAAAA | PhosphoSitePlus | |
| Y531 | RRAMAyETLEQ | TPR_1 | PhosphoSitePlus |
| T661 | ECAIYtNRALC | TPR_1 | PhosphoSitePlus |
| S354 | DEEGKsGRKHE | PhosphoSitePlus | |
| Y639 | VNDKNyKDALS | TPR_2 | PhosphoSitePlus |
| Y660 | KECAIyTNRAL | TPR_1 | PhosphoSitePlus |
| S603 | AKEMIsKQAGD | PhosphoSitePlus | |
| S330 | NSEAAsETQTK | PhosphoSitePlus | |
| S317 | AKKTLsEVERD | PRKCA | HPRD |
| S317 | AKKTLsEVERD | PKCa | RegPhos |
| Y6 | MTTKDyPSLWG | PhosphoSitePlus | |
| Y870 | DPSLVyQHLLY | PhosphoSitePlus | |
| Y537 | ETLEQyGKAYV | TPR_1 | PhosphoSitePlus |
| Y177 | KIDEDyKEKTV | PhosphoSitePlus; RegPhos | |
| S347 | QEIENsEDEEG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T334 | ASETQtKGKRM | PhosphoSitePlus | |
| S791 | GKSSRsPEDPE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S418 | GADKRsPRRAS | PhosphoSitePlus | |
| S647 | ALSKYsECLKI | TPR_2 | PhosphoSitePlus |
| Y875 | YQHLLyLSKAE | PhosphoSitePlus | |
| S326 | RDLKNsEAASE | PhosphoSitePlus | |
| Y646 | DALSKySECLK | TPR_2 | PhosphoSitePlus |
| Dephosphorylation site |
| SPAG1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000373450 | S581* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000373450 | S581* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000251809 | N715- | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000251809 | S581* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000373450 | G607E | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000373450 | N715- | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000373450 | M777I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000251809 | G607E | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 |
| Differential expressed protein |
| SPAG1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SPAG1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | SPAG1_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | SPAG1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| SPAG1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007338 | single fertilization | IEA | biological_process |