Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPAG1_HUMAN
Description:sperm associated antigen 1 [Source:HGNC Symbol;Acc:11212]
Location:chr8 q22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y225FNSGDyEEAVMTPR_1; MITPhosphoSitePlus
T618RQQGItDEKTFPhosphoSitePlus
S72ALAPEsRALRKPhosphoSitePlus
S423SPRRAsAAAAAPhosphoSitePlus
Y531RRAMAyETLEQTPR_1PhosphoSitePlus
T661ECAIYtNRALCTPR_1PhosphoSitePlus
S354DEEGKsGRKHEPhosphoSitePlus
Y639VNDKNyKDALSTPR_2PhosphoSitePlus
Y660KECAIyTNRALTPR_1PhosphoSitePlus
S603AKEMIsKQAGDPhosphoSitePlus
S330NSEAAsETQTKPhosphoSitePlus
S317AKKTLsEVERDPRKCAHPRD
S317AKKTLsEVERDPKCaRegPhos
Y6MTTKDyPSLWGPhosphoSitePlus
Y870DPSLVyQHLLYPhosphoSitePlus
Y537ETLEQyGKAYVTPR_1PhosphoSitePlus
Y177KIDEDyKEKTVPhosphoSitePlus; RegPhos
S347QEIENsEDEEGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T334ASETQtKGKRMPhosphoSitePlus
S791GKSSRsPEDPEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S418GADKRsPRRASPhosphoSitePlus
S647ALSKYsECLKITPR_2PhosphoSitePlus
Y875YQHLLyLSKAEPhosphoSitePlus
S326RDLKNsEAASEPhosphoSitePlus
Y646DALSKySECLKTPR_2PhosphoSitePlus

Dephosphorylation site
SPAG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000373450S581*TCGAOvarian Cancer21720365, 18772890
ENSP00000373450S581*COSMICOvarian Cancer21720365
ENSP00000251809N715-BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000251809S581*TCGAOvarian Cancer21720365, 18772890
ENSP00000373450G607ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000373450N715-BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000373450M777ICOSMICHead and Neck Cancer21798893
ENSP00000251809G607EBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
SPAG1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SPAG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANSPAG1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANSPAG1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
SPAG1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016787hydrolase activityIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0007338single fertilizationIEAbiological_process


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