| UniProt/SwissProt ID: | SP4_HUMAN |
| Description: | Sp4 transcription factor [Source:HGNC Symbol;Acc:11209] |
| Location: | chr7 p15.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S126 | ASSSSsSSSSN | PhosphoSitePlus | |
| T138 | GSASPtKTKSG | PhosphoSitePlus; HPRD; phosphoELM | |
| T20 | AAAMAtEGGKT | PhosphoSitePlus | |
| T700 | QRHRRtHTGEK | zf-C2H2 | PhosphoSitePlus |
| S130 | SSSSSsNNGSA | PhosphoSitePlus | |
| S125 | PASSSsSSSSS | PhosphoSitePlus | |
| S127 | SSSSSsSSSNN | PhosphoSitePlus | |
| T774 | DSNPAtPNVST | PhosphoSitePlus | |
| S767 | TVAAIsQDSNP | HPRD | |
| S691 | KRFTRsDELQR | zf-C2H2 | PhosphoSitePlus; SysPTM |
| S136 | NNGSAsPTKTK | PhosphoSitePlus; HPRD | |
| S770 | AISQDsNPATP | PhosphoSitePlus | |
| S691 | KRFTRsDELQR | HPRD; phosphoELM; SysPTM | |
| T672 | HLRWHtGERPF | PhosphoSitePlus | |
| S124 | QPASSsSSSSS | PhosphoSitePlus | |
| T702 | HRRTHtGEKRF | PhosphoSitePlus | |
| Dephosphorylation site |
| SP4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000222584 | D388E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000222584 | R665* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000222584 | R665* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000222584 | I648V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000222584 | P628L | COSMIC | Melanoma | 21499247 | ENSP00000222584 | Q415E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000222584 | Q415E | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000222584 | D388E | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| SP4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SP4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP4_HUMAN | HAND1_HUMAN | TF -> target gene | TRANSFAC |
| SP4_HUMAN | CCND1_HUMAN | TF -> target gene | TRANSFAC |
| SP4_HUMAN | PHX2A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SP4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | IDA | biological_process |