Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOX2_HUMAN
Description:SRY (sex determining region Y)-box 2 [Source:HGNC Symbol;Acc:11195]
Location:chr3 q26.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S251SEASSsPPVVTPhosphoSitePlus; HPRD
S249VKSEAsSSPPVPhosphoSitePlus; HPRD
T126KKDKYtLPGGLSOXpPhosphoSitePlus
T118RRKTKtLMKKDSOXpPhosphoSitePlus
S138APGGNsMASGVSOXpPhosphoSitePlus
S250KSEASsSPPVVPhosphoSitePlus; HPRD
S37GNQKNsPDRVKPhosphoSitePlus
S246GSVVKsEASSSPhosphoSitePlus
Y125MKKDKyTLPGGSOXpPhosphoSitePlus

Dephosphorylation site
SOX2_HUMAN do not have dephosphorylation site.

Mutation site
SOX2_HUMAN do not have mutation site.

Differential expressed protein
SOX2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOX2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAK1_HUMANSOX2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANSOX2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SOX2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003677DNA bindingIEAmolecular_function
GO:0050973detection of mechanical stimulus involved in equilIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0050910detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0030539male genitalia developmentIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process
GO:0030858positive regulation of epithelial cell differentiaIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0001714endodermal cell fate specificationIDAbiological_process
GO:0000976transcription regulatory region sequence-specific IEAmolecular_function
GO:0001654eye developmentIEPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0001708cell fate specificationIEAbiological_process
GO:0035019somatic stem cell maintenanceIMPbiological_process
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0019827stem cell maintenanceIEAbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0009611response to woundingIEPbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0001649osteoblast differentiationIDAbiological_process
GO:0043586tongue developmentIEAbiological_process
GO:0035198miRNA bindingIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0048568embryonic organ developmentIEAbiological_process
GO:0070848response to growth factor stimulusIDAbiological_process
GO:0005634nucleusICcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0021984adenohypophysis developmentIEAbiological_process
GO:0021781glial cell fate commitmentNASbiological_process
GO:0005829cytosolIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0002052positive regulation of neuroblast proliferationIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0010468regulation of gene expressionIMPbiological_process
GO:0030910olfactory placode formationIEAbiological_process
GO:0060042retina morphogenesis in camera-type eyeIEAbiological_process
GO:0042221response to chemical stimulusIEAbiological_process
GO:0006325chromatin organizationNASbiological_process
GO:0005667transcription factor complexTAScellular_component
GO:0030900forebrain developmentIEPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043281regulation of cysteine-type endopeptidase activityIDAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0021879forebrain neuron differentiationIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIDAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0007605sensory perception of soundIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0060235lens induction in camera-type eyeIEAbiological_process
GO:0021983pituitary gland developmentIEPbiological_process
GO:0046148pigment biosynthetic processIEAbiological_process
GO:0045747positive regulation of Notch signaling pathwayIEAbiological_process
GO:0048286lung alveolus developmentIEAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0048863stem cell differentiationIEAbiological_process
GO:0097150neuronal stem cell maintenanceISSbiological_process
GO:0048852diencephalon morphogenesisIEAbiological_process
GO:0032526response to retinoic acidIEAbiological_process
GO:0045665negative regulation of neuron differentiationISSbiological_process
GO:0048839inner ear developmentIEPbiological_process