| UniProt/SwissProt ID: | AAK1_HUMAN |
| Description: | AP2 associated kinase 1 [Source:HGNC Symbol;Acc:19679] |
| Location: | chr2 p13.3 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S327 | PNVQNsPIPAK | HPRD | |
| S235 | MVNLYsGKIIT | Pkinase | PhosphoSitePlus |
| S327 | PNVQNsPIPAK | Pkinase | PhosphoSitePlus |
| T389 | IQPALtPRKRA | PhosphoSitePlus; HPRD; phosphoELM | |
| S18 | GSGLGsGSSGG | PhosphoSitePlus; HPRD | |
| T852 | QTESVtSNRTD | PhosphoSitePlus | |
| S624 | LTPPSsPKTQR | PhosphoSitePlus; HPRD; phosphoELM | |
| T681 | SGSPRtSQQNV | HPRD | |
| T627 | PSSPKtQRAGH | PhosphoSitePlus | |
| S642 | SDVTHsAVFGV | PhosphoSitePlus | |
| Y234 | EMVNLySGKII | HPRD; phosphoELM | |
| T354 | PKARLtDPIPT | PhosphoSitePlus | |
| Y292 | HCLIRyMLEPD | HPRD | |
| S652 | VPASKsTQLLQ | PhosphoSitePlus | |
| Y292 | HCLIRyMLEPD | Pkinase | PhosphoSitePlus |
| S20 | GLGSGsSGGGG | PhosphoSitePlus; HPRD | |
| S618 | GQKVGsLTPPS | PhosphoSitePlus; HPRD; phosphoELM | |
| S682 | GSPRTsQQNVY | PhosphoSitePlus; HPRD | |
| Y234 | EMVNLySGKII | Pkinase | PhosphoSitePlus |
| T222 | IKKYTtLSYRA | HPRD; phosphoELM | |
| T359 | TDPIPtTETSI | PhosphoSitePlus | |
| T674 | KSATTtPSGSP | PhosphoSitePlus; HPRD | |
| T653 | PASKStQLLQA | PhosphoSitePlus | |
| S235 | MVNLYsGKIIT | HPRD; phosphoELM | |
| Y253 | LGCLLyKLCYF | Pkinase | PhosphoSitePlus |
| T221 | EIKKYtTLSYR | HPRD; phosphoELM | |
| S637 | HRRILsDVTHS | PhosphoSitePlus; HPRD; phosphoELM | |
| T640 | ILSDVtHSAVF | PhosphoSitePlus; HPRD; phosphoELM | |
| S21 | LGSGSsGGGGS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y34 | GLGSGyIGRVF | PhosphoSitePlus | |
| S650 | FGVPAsKSTQL | PhosphoSitePlus | |
| S14 | REQGGsGLGSG | PhosphoSitePlus; HPRD | |
| S690 | NVYNPsEGSTW | PhosphoSitePlus | |
| T606 | PKVQTtPPPAV | PhosphoSitePlus; HPRD; phosphoELM | |
| T620 | KVGSLtPPSSP | PhosphoSitePlus; HPRD; phosphoELM | |
| T848 | RLPSQtESVTS | PhosphoSitePlus | |
| Y687 | SQQNVyNPSEG | PhosphoSitePlus | |
| S623 | SLTPPsSPKTQ | PhosphoSitePlus; HPRD; phosphoELM | |
| T441 | PQAPPtPQQTP | PhosphoSitePlus; HPRD | |
| S668 | ASLNKsKSATT | PhosphoSitePlus; HPRD | |
| T347 | AAAKKtQPKAR | PhosphoSitePlus | |
| S670 | LNKSKsATTTP | PhosphoSitePlus; HPRD; phosphoELM | |
| S731 | EKLGGsAESLI | PhosphoSitePlus; HPRD | |
| T27 | GGGGStSGLGS | HPRD | |
| S846 | PQRLPsQTESV | PhosphoSitePlus | |
| S676 | ATTTPsGSPRT | PhosphoSitePlus; HPRD; phosphoELM | |
| T362 | IPTTEtSIAPR | PhosphoSitePlus | |
| S678 | TTPSGsPRTSQ | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| AAK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000385181 | P679R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385181 | R141H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000386456 | P679R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000386456 | R141H | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| AAK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AAK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AAK1_HUMAN | SOX2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| AAK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005905 | coated pit | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0043195 | terminal button | ISS | cellular_component |
| GO:0050821 | protein stabilization | IDA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:2000369 | regulation of clathrin-mediated endocytosis | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019897 | extrinsic to plasma membrane | ISS | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | ISS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | ISS | molecular_function |
| GO:0032880 | regulation of protein localization | IDA | biological_process |
| GO:0005112 | Notch binding | IDA | molecular_function |
| GO:0035612 | AP-2 adaptor complex binding | IDA | molecular_function |
| GO:0030136 | clathrin-coated vesicle | ISS | cellular_component |
| GO:0045747 | positive regulation of Notch signaling pathway | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0031252 | cell leading edge | ISS | cellular_component |