Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SORT_HUMAN
Description:sortilin 1 [Source:HGNC Symbol;Acc:11186]
Location:chr1 p13.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S819SHTNKsGYHDDPhosphoSitePlus; HPRD
S825GYHDDsDEDLHPRD; phosphoELM; SysPTM
T185GKVVLtAEVSGHPRD
Y821TNKSGyHDDSDPhosphoSitePlus
T168NTFIRtEFGMAHPRD
S793LVHRYsVLQQHPhosphoSitePlus
S305GVKIYsFGLGGHPRD
S825GYHDDsDEDLLPhosphoSitePlus; SysPTM
T298GKSFKtIGVKIPhosphoSitePlus; HPRD

Dephosphorylation site
SORT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256637A762GCOSMICOvarian Cancer21720365
ENSP00000256637G720ECOSMICSkin Cancer21984974

Differential expressed protein
SORT_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SORT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NGF_HUMANSORT_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04142Lysosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIDAcellular_component
GO:0031965nuclear membraneIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0006895Golgi to endosome transportIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0010008endosome membraneIEAcellular_component
GO:0007218neuropeptide signaling pathwayIDAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayIMPbiological_process
GO:0051005negative regulation of lipoprotein lipase activityIDAbiological_process
GO:0048406nerve growth factor bindingIPImolecular_function
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0046323glucose importIMPbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0097190apoptotic signaling pathwayIMPbiological_process
GO:0032868response to insulin stimulusIMPbiological_process
GO:0005765lysosomal membraneIEAcellular_component
GO:0032509endosome transport via multivesicular body sortingIDAbiological_process
GO:0016050vesicle organizationIDAbiological_process
GO:0030379neurotensin receptor activity, non-G-protein couplIDAmolecular_function
GO:0008333endosome to lysosome transportIDAbiological_process
GO:0010468regulation of gene expressionIMPbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0014902myotube differentiationIMPbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0030140trans-Golgi network transport vesicleIEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0010465nerve growth factor receptor activityIDAmolecular_function
GO:0032580Golgi cisterna membraneIEAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0046323glucose importIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005905coated pitIDAcellular_component
GO:0048227plasma membrane to endosome transportIDAbiological_process
GO:0016050vesicle organizationIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0014902myotube differentiationIEAbiological_process
GO:0006897endocytosisIDAbiological_process
GO:0005768endosomeNAScellular_component
GO:0005769early endosomeIDAcellular_component
GO:0030136clathrin-coated vesicleIDAcellular_component
GO:0001503ossificationIEAbiological_process


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