| UniProt/SwissProt ID: | SORL_HUMAN |
| Description: | sortilin-related receptor, L(DLR class) A repeats containing [Source:HGNC Symbol;Acc:11185] |
| Location: | chr11 q24.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S82 | LRRKRsAALQP | PhosphoSitePlus | |
| Y139 | DVYVSyDYGKS | PhosphoSitePlus | |
| T1824 | SAWAKtDLGDS | fn3 | PhosphoSitePlus |
| T598 | KSTVFtIFGSN | PhosphoSitePlus | |
| S375 | TNLYIsEAEGL | PhosphoSitePlus | |
| S322 | GSEQQsSVQLW | HPRD | |
| S329 | VQLWVsFGRKP | HPRD | |
| T1811 | KVGNLtAHTSY | fn3 | PhosphoSitePlus |
| S114 | WAGEKsNVIVA | PhosphoSitePlus; HPRD | |
| S318 | VHLLGsEQQSS | HPRD | |
| S2206 | MITGFsDDVPM | PhosphoSitePlus | |
| Y1874 | VYGIFyATSFL | PhosphoSitePlus | |
| Y1719 | LVNTLyTVRVA | fn3 | PhosphoSitePlus |
| Y136 | KSSDVyVSYDY | PhosphoSitePlus | |
| S2167 | HRRLQsSFTAF | PhosphoSitePlus | |
| S385 | LKFSLsLENVL | PhosphoSitePlus | |
| S499 | ILSKEsAPGLI | PhosphoSitePlus | |
| Dephosphorylation site |
| SORL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000260197 | L1972V | HPI | Colorectal Cancer | 16959974 | ENSP00000260197 | G622C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000260197 | Y934D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000260197 | P1213S | COSMIC | Skin Cancer | 21984974 | ENSP00000260197 | M1581L | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000260197 | E348K | COSMIC | Melanoma | 21499247 | ENSP00000260197 | V96A | COSMIC | Skin Cancer | 21984974 | ENSP00000260197 | N466S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260197 | N466S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000260197 | L120S | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000260197 | Y728C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000260197 | M1581fs*34 | COSMIC | Breast Cancer | 17932254 | ENSP00000260197 | D1267N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260197 | G622* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260197 | L1908V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000260197 | Y728C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260197 | Y1136C | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000260197 | L1972V | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| SORL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SORL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| APOE_HUMAN | SORL_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| SORL_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034362 | low-density lipoprotein particle | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0006898 | receptor-mediated endocytosis | TAS | biological_process |
| GO:0008203 | cholesterol metabolic process | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006869 | lipid transport | IEA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0030169 | low-density lipoprotein particle binding | IPI | molecular_function |