| UniProt/SwissProt ID: | SNP25_HUMAN |
| Description: | synaptosomal-associated protein, 25kDa [Source:HGNC Symbol;Acc:11132] |
| Location: | chr20 p12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S187 | MEKADsNKTRI | Exonuc_VII_L; SNARE | PhosphoSitePlus |
| S187 | MEKADsNKTRI | PRKCA | HPRD |
| T138 | FIRRVtNDARE | PRKCA | HPRD |
| T138 | FIRRVtNDARE | PKCa | RegPhos |
| T29 | ESLEStRRMLQ | IncA; Sec34; Exonuc_VII_L | PhosphoSitePlus |
| S187 | MEKADsNKTRI | PKCa | RegPhos |
| S187 | MEKADsNKTRI | RegPhos | |
| T138 | FIRRVtNDARE | RegPhos | |
| S28 | DESLEsTRRML | IncA; Sec34; Exonuc_VII_L | PhosphoSitePlus |
| T138 | FIRRVtNDARE | PRKACA | HPRD |
| T138 | FIRRVtNDARE | Exonuc_VII_L; SNAP-25 | PhosphoSitePlus |
| T138 | FIRRVtNDARE | PKACa | RegPhos |
| Dephosphorylation site |
| SNP25_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000307341 | R59C | COSMIC | Melanoma | 21499247 | ENSP00000307341 | Q56* | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| SNP25_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SNP25_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | SNP25_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | SNP25_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04721 | Synaptic vesicle cycle |
| hsa04130 | SNARE interactions in vesicular transport |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045202 | synapse | IEA | cellular_component |
| GO:0007268 | synaptic transmission | NAS | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0031083 | BLOC-1 complex | IDA | cellular_component |
| GO:0031201 | SNARE complex | ISS | cellular_component |
| GO:0005802 | trans-Golgi network | IEA | cellular_component |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0050796 | regulation of insulin secretion | TAS | biological_process |
| GO:0014047 | glutamate secretion | TAS | biological_process |
| GO:0005737 | cytoplasm | ISS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007269 | neurotransmitter secretion | IEA | biological_process |
| GO:0000149 | SNARE binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I co | IEA | cellular_component |
| GO:0001504 | neurotransmitter uptake | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030426 | growth cone | ISS | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016020 | membrane | ISS | cellular_component |
| GO:0016192 | vesicle-mediated transport | IEA | biological_process |
| GO:0043005 | neuron projection | ISS | cellular_component |
| GO:0016081 | synaptic vesicle docking involved in exocytosis | NAS | biological_process |
| GO:0007269 | neurotransmitter secretion | NAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |