| UniProt/SwissProt ID: | SNIP1_HUMAN |
| Description: | Smad nuclear interacting protein 1 [Source:HGNC Symbol;Acc:30587] |
| Location: | chr1 p34.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S52 | DHSGGsPSPPT | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S99 | SKRNRsPHHST | PhosphoSitePlus; HPRD | |
| Y350 | EPQRYyELKEK | FHA | PhosphoSitePlus |
| S35 | KQERLsPEVAP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S128 | QHREPsEQEHR | PhosphoSitePlus | |
| S91 | GRRSKsPRSKR | HPRD | |
| S200 | VGGGGsESQEL | PhosphoSitePlus | |
| T104 | SPHHStVKVKQ | PhosphoSitePlus; HPRD | |
| S394 | EEEEVs | HPRD; SysPTM | |
| S54 | SGGSPsPPTSE | PhosphoSitePlus; HPRD; phosphoELM | |
| S153 | HQRRTsNERPG | PhosphoSitePlus; HPRD; SysPTM | |
| T152 | SHQRRtSNERP | PhosphoSitePlus; HPRD | |
| S74 | RARGVsRSPPK | PhosphoSitePlus; HPRD | |
| S202 | GGGSEsQELVP | PhosphoSitePlus; HPRD; phosphoELM | |
| S394 | EEEEVsDS___ | PhosphoSitePlus; SysPTM | |
| S76 | RGVSRsPPKKK | PhosphoSitePlus; HPRD | |
| S159 | NERPGsGQGQG | PhosphoSitePlus; HPRD | |
| T169 | GRDRDtQNLQA | PhosphoSitePlus; HPRD; phosphoELM | |
| T236 | ALLEDtNTFRG | HPRD | |
| S89 | ASGRRsKSPRS | HPRD | |
| S12 | ERERGsRRRHR | PhosphoSitePlus | |
| S396 | EEVSDs_____ | PhosphoSitePlus | |
| Y349 | IEPQRyYELKE | FHA | PhosphoSitePlus |
| S49 | RRPDHsGGSPS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| SNIP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296215 | E217Q | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000296215 | E248K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000296215 | R322Q | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SNIP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SNIP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | SNIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SNIP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035196 | production of miRNAs involved in gene silencing by | IMP | biological_process |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | IEA | biological_process |