Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMC1A_HUMAN
Description:structural maintenance of chromosomes 1A [Source:HGNC Symbol;Acc:11111]
Location:chrX p11.22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S966DSVSGsQRISSSMC_NPhosphoSitePlus
S957QEEGSsQGEDSATMHPRD; phosphoELM; RegPhos
Y575FLPLDyLEVKPSMC_N; SMC_hingePhosphoSitePlus
S360EEESQsQGRDLHPRD; phosphoELM; RegPhos
Y600IDVIRyEPPHISMC_N; SMC_hingePhosphoSitePlus
T366QGRDLtLEENQSMC_NPhosphoSitePlus
S657ISGGAsDLKAKSMC_NPhosphoSitePlus
S971SQRISsIYAREHPRD; phosphoELM
S735NLQEKsKLESEphosphoELM
S957QEEGSsQGEDSSMC_NPhosphoSitePlus
Y973RISSIyAREALSMC_NPhosphoSitePlus
Y168ELAQEyDKRKKSMC_NPhosphoSitePlus
S970GSQRIsSIYARSMC_NPhosphoSitePlus
S653KSGVIsGGASDSMC_NPhosphoSitePlus
S735NLQEKsKLESESMC_NPhosphoSitePlus
S970GSQRIsSIYARHPRD; phosphoELM
T28PFQRFtAIIGPSMC_NPhosphoSitePlus
S715MRLKYsQSDLESMC_NPhosphoSitePlus
T28PFQRFtAIIGPHPRD
Y973RISSIyAREALHPRD; phosphoELM
S966DSVSGsQRISSATMHPRD; phosphoELM; RegPhos
S966DSVSGsQRISSATRRegPhos
S962SQGEDsVSGSQSMC_NPhosphoSitePlus
S1033MEKLEsVRDKFphosphoELM
S951TMDDIsQEEGSSMC_NPhosphoSitePlus
T841HMWEQtVKKDEHPRD
S964GEDSVsGSQRISMC_NPhosphoSitePlus
T1217ISKVLtFDLTKPhosphoSitePlus
S703LRQVQsQAHGLSMC_NPhosphoSitePlus
S1033MEKLEsVRDKFSMC_N; DUF848PhosphoSitePlus
Y714QMRLKySQSDLSMC_NPhosphoSitePlus
S966DSVSGsQRISSphosphoELM
T722SDLEQtKTRHLHPRD
T1221LTFDLtKYPDAPhosphoSitePlus
S956SQEEGsSQGEDSMC_NPhosphoSitePlus
S957QEEGSsQGEDSHPRD; phosphoELM; RegPhos
Y600IDVIRyEPPHIphosphoELM
S360EEESQsQGRDLSMC_NPhosphoSitePlus
S358RMEEEsQSQGRSMC_NPhosphoSitePlus
S358RMEEEsQSQGRHPRD; phosphoELM; RegPhos
Y530PTQKKyQIAVTSMC_N; SMC_hingePhosphoSitePlus
S964GEDSVsGSQRIHPRD; phosphoELM
S962SQGEDsVSGSQHPRD; phosphoELM; RegPhos
S956SQEEGsSQGEDHPRD; phosphoELM
Y611KKALQyACGNASMC_N; SMC_hingePhosphoSitePlus
S951TMDDIsQEEGSHPRD; phosphoELM; RegPhos

Dephosphorylation site
SMC1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000323421P512HCOSMICOvarian Cancer21720365
ENSP00000323421Q432PCOSMICCentral Nervous System Neoplasms21163964
ENSP00000323421D582YCOSMICOvarian Cancer21720365
ENSP00000323421T182ACOSMICHead and Neck Cancer21984974
ENSP00000323421R895HCOSMICOvarian Cancer21720365
ENSP00000323421G35VCOSMICHead and Neck Cancer21798893
ENSP00000323421R626HCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000323421Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000323421Pancreatic CancerNormal vs. CancertissueUp1.416212428
ENSP00000323421Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000323421Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S966SMC_NGEDSVSGsQRISSIYataxia-telangiectasic cancer12447382PhosphoSitePlus
S966SMC_NGEDSVSGsQRISSIYRIDDLE syndrome17940005PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSMC1A_HUMANkinase -> substrateRegPhos
ATM_HUMANSMC1A_HUMANkinase -> substrateRegPhos
ATR_HUMANSMC1A_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003777microtubule motor activityNASmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0003682chromatin bindingIDAmolecular_function
GO:0000236mitotic prometaphaseTASbiological_process
GO:0006310DNA recombinationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0032876negative regulation of DNA endoreduplicationIMPbiological_process
GO:0036033mediator complex bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0009314response to radiationIEPbiological_process
GO:0000075cell cycle checkpointIDAbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0030893meiotic cohesin complexIDAcellular_component
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0019827stem cell maintenanceIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0051276chromosome organizationIEAbiological_process
GO:0042770signal transduction in response to DNA damageIDAbiological_process
GO:0008280cohesin core heterodimerTAScellular_component
GO:0030261chromosome condensationIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0005694chromosomeIEAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0007052mitotic spindle organizationTASbiological_process
GO:0007091mitotic metaphase/anaphase transitionTASbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0000398mRNA splicing, via spliceosomeTASbiological_process
GO:0007064mitotic sister chromatid cohesionTASbiological_process
GO:0000070mitotic sister chromatid segregationTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0007126meiosisISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0000794condensed nuclear chromosomeTAScellular_component
GO:0051301cell divisionIEAbiological_process
GO:0007062sister chromatid cohesionIMPbiological_process


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