| UniProt/SwissProt ID: | SMAL1_HUMAN |
| Description: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 [Source:HGNC Symbol;Acc:11102] |
| Location: | chr2 q35 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S952 | WDSFTsPL___ | PhosphoSitePlus | |
| S533 | SFDLLsKLEKQ | SNF2_N | PhosphoSitePlus |
| S528 | LINIVsFDLLS | SNF2_N | PhosphoSitePlus |
| Y872 | TESTDyLYKDP | PhosphoSitePlus | |
| S198 | KTAKAsPSGQN | HPRD; phosphoELM | |
| T867 | NFSEMtESTDY | HPRD | |
| S627 | WDYSGsSNLGE | SNF2_N | PhosphoSitePlus |
| T157 | PEIRFtPFANP | PhosphoSitePlus | |
| Y306 | PLEWAyGSSES | PhosphoSitePlus | |
| S172 | LAKPKsSQETP | PhosphoSitePlus | |
| S112 | ACPGHsPRSQM | PhosphoSitePlus | |
| S151 | GHAQAsPEIRF | PhosphoSitePlus; HPRD | |
| Y874 | STDYLyKDPKQ | PhosphoSitePlus | |
| S211 | YIHSSsESVTP | PhosphoSitePlus | |
| S181 | TPAHSsGQPPR | PhosphoSitePlus | |
| S652 | KSDVLsQLPAK | SNF2_N | PhosphoSitePlus |
| T215 | SSESVtPRTEG | PhosphoSitePlus | |
| Dephosphorylation site |
| SMAL1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000349823 | P199R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000350940 | A355V | COSMIC | Melanoma | ENSP00000350940 | P199R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350940 | L432V | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000349823 | A355V | COSMIC | Melanoma | ENSP00000349823 | F886L | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000349823 | L432V | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000349823 | P199R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350940 | P199R | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| SMAL1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SMAL1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK3_HUMAN | SMAL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SMAL1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008094 | DNA-dependent ATPase activity | IEA | molecular_function |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IMP | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000733 | DNA strand renaturation | IMP | biological_process |
| GO:0036310 | annealing helicase activity | IMP | molecular_function |
| GO:0006259 | DNA metabolic process | IMP | biological_process |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |