| UniProt/SwissProt ID: | SLPI_HUMAN |
| Description: | secretory leukocyte peptidase inhibitor [Source:HGNC Symbol;Acc:11092] |
| Location: | chr20 q13.12 |
| Node attribute: | gene |
| Phosphorylation site |
| SLPI_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| SLPI_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000342082 | L10V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000342082 | *133K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000342082 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 0.05 | 16215274 | ENSP00000342082 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 17902640 |
| Hyperphosphorylation site |
| SLPI_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IRF1_HUMAN | SLPI_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SLPI_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032091 | negative regulation of protein binding | IDA | biological_process |
| GO:0004866 | endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0010951 | negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0030414 | peptidase inhibitor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045071 | negative regulation of viral genome replication | IDA | biological_process |