Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SLK_HUMAN
Description:STE20-like kinase [Source:HGNC Symbol;Acc:11088]
Location:chr10 q24.33
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1097INSTAtPDQDRHPRD; SysPTM
S1235LHSTGs_____PhosphoSitePlus; SysPTM
S754DSGTGsTADTSHPRD
S816KIVTDsDSKTEPhosphoSitePlus; HPRD
S623EQAINsSENIMHPRD
T527LTKEDtQEKLGHPRD
S57QNKETsVLAAAPkinasePhosphoSitePlus
S1094SLRINsTATPDHPRD
S546VISNTsDVIGTPhosphoSitePlus; HPRD; SysPTM
T181VSAKNtRTIQRPkinasePhosphoSitePlus
S777SKTKDsGSISLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S341SKRASsDLSIAPhosphoSitePlus; HPRD
T569DSAEDtQSNDGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1089AMFKKsLRINSPKKPhosphoSitePlus
T1188RPRKKtLEEEFPhosphoSitePlus
S189IQRRDsFIGTPHPRD; phosphoELM; SysPTM
S1232IPSLHsTHPRD
S14IFKLGsEKKKKPhosphoSitePlus
S1219NPSTQsRISKFPhosphoSitePlus
T139VVCKQtLDALNPkinasePhosphoSitePlus
S759STADTsSIDLNHPRD
T636NEEPGtTEGEEHPRD
S565KVDEDsAEDTQPhosphoSitePlus; HPRD
S818VTDSDsKTEELPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y1052EQMQRyNQRLIPKKPhosphoSitePlus
S717SININsDSGENHPRD
S518IQAVDsEVGLTPhosphoSitePlus
S2FNFRHPRD
T551SDVIGtCEAADPhosphoSitePlus
S571AEDTQsNDGKEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S189IQRRDsFIGTPPkinasePhosphoSitePlus; SysPTM
T183AKNTRtIQRRDHPRD
T676DASKVtTQIDKHPRD
S647ITESSsTEEMEHPRD
S344ASSDLsIASSEPhosphoSitePlus; HPRD
S362ACILEsVSEKTPhosphoSitePlus
Y214DRPYDyKADVWPkinasePhosphoSitePlus
T183AKNTRtIQRRDPkinasePhosphoSitePlus
S348LSIASsEEDKLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y1225RISKFyPIPSLPhosphoSitePlus
S1229FYPIPsLHSTHPRD
S645EEITEsSSTEEHPRD
S330EETENsLPIPAPhosphoSitePlus; HPRD; SysPTM
S772ISSFLsKTKDSPhosphoSitePlus; HPRD; phosphoELM
S781DSGSIsLQETRPhosphoSitePlus
T523SEVGLtKEDTQHPRD
S354EEDKLsQNACIPhosphoSitePlus; HPRD; phosphoELM
T139VVCKQtLDALNHPRD
S779TKDSGsISLQEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S646EITESsSTEEMPhosphoSitePlus; HPRD
S370EKTERsNSEDKPhosphoSitePlus; HPRD; SysPTM
S340ASKRAsSDLSIPhosphoSitePlus; HPRD; SysPTM
T785ISLQEtRRQKKPhosphoSitePlus; HPRD
T545DVISNtSDVIGPhosphoSitePlus
T755SGTGStADTSSPhosphoSitePlus; HPRD; phosphoELM
T637EEPGTtEGEEIHPRD
S177ADFGVsAKNTRPkinasePhosphoSitePlus
T193DSFIGtPYWMAPkinasePhosphoSitePlus
S347DLSIAsSEEDKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1229FYPIPsLHSTGPhosphoSitePlus
T181VSAKNtRTIQRHPRD
Y212SKDRPyDYKADPkinasePhosphoSitePlus
S2____MsFFNFRPhosphoSitePlus
T752DNDSGtGSTADHPRD
T814TSKIVtDSDSKPhosphoSitePlus
Y195FIGTPyWMAPEPkinasePhosphoSitePlus
T1233PSLHStHPRD
S750ENDNDsGTGSTHPRD
S1235LHSTHPRD; phosphoELM; SysPTM
T327DEEEEtENSLPHPRD
Y195FIGTPyWMAPEHPRD; phosphoELM
T1097INSTAtPDQDRPKKPhosphoSitePlus; SysPTM
T193DSFIGtPYWMAHPRD; phosphoELM
T1095LRINStATPDQHPRD
S655EMEVRsVVADTPhosphoSitePlus; HPRD; SysPTM
S543QKDVIsNTSDVHPRD
T820DSDSKtEELRFPhosphoSitePlus

Dephosphorylation site
SLK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358770Q405KHPILung Cancer17344846
ENSP00000358770E912*TCGAOvarian Cancer21720365, 18772890
ENSP00000358770E604QHPIOvarian Cancer17344846

Differential expressed protein
SLK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SLK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SLK_HUMANTAOK3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006915apoptotic processIEAbiological_process


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