Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SLIT2_HUMAN
Description:slit homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:11086]
Location:chr4 p15.31
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T489YFIPGtEDYRSPhosphoSitePlus
Y484SAKEQyFIPGTPhosphoSitePlus
Y492PGTEDyRSKLSPhosphoSitePlus
S479KKFRCsAKEQYPhosphoSitePlus
S135YRLDLsENQIQLRR_4PhosphoSitePlus
S1510ECTDGsSFVDEPhosphoSitePlus

Dephosphorylation site
SLIT2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000422591L540FBIOMARTBreast Cancer21930507, 21930502
ENSP00000422261C1352WBIOMARTBreast Cancer21930507, 21930502
ENSP00000422591P1387RTCGAOvarian Cancer21720365, 18772890
ENSP00000422591V999IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000422591A412TBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000422591N775STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000427548A412TBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000422591C1356WBIOMARTBreast Cancer21930507, 21930502
ENSP00000422261V995IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000427548P1253TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000422591P1261TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000427548L532FBIOMARTBreast Cancer21930507, 21930502
ENSP00000422261P1257TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000422261A416TBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000427548C1348WBIOMARTBreast Cancer21930507, 21930502
ENSP00000422261L536FBIOMARTBreast Cancer21930507, 21930502
ENSP00000427548V991IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000422591A276TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
SLIT2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SLIT2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SLIT2_HUMANROBO4_HUMANligand -> receptorHPMR
SLIT2_HUMANGPC1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005615extracellular spaceIDAcellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0008045motor neuron axon guidanceIDAbiological_process
GO:0016337cell-cell adhesionIEAbiological_process
GO:0060603mammary gland duct morphogenesisIEAbiological_process
GO:0048495Roundabout bindingIPImolecular_function
GO:0071504cellular response to heparinIDAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0031290retinal ganglion cell axon guidanceIDAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0032870cellular response to hormone stimulusIEPbiological_process
GO:0001933negative regulation of protein phosphorylationIDAbiological_process
GO:0050919negative chemotaxisIEAbiological_process
GO:0050919negative chemotaxisIDAbiological_process
GO:0061364apoptotic process involved in luteolysisIEPbiological_process
GO:0022029telencephalon cell migrationIEAbiological_process
GO:0043237laminin-1 bindingIDAmolecular_function
GO:0016020membraneNAScellular_component
GO:0021772olfactory bulb developmentIEAbiological_process
GO:0051414response to cortisol stimulusIEPbiological_process
GO:0005509calcium ion bindingNASmolecular_function
GO:0090027negative regulation of monocyte chemotaxisISSbiological_process
GO:0007411axon guidanceIDAbiological_process
GO:0050929induction of negative chemotaxisIDAbiological_process
GO:0030308negative regulation of cell growthIMPbiological_process
GO:0070100negative regulation of chemokine-mediated signalinIMPbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0033563dorsal/ventral axon guidanceIEAbiological_process
GO:0002689negative regulation of leukocyte chemotaxisIDAbiological_process
GO:0031290retinal ganglion cell axon guidanceIEAbiological_process
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0030336negative regulation of cell migrationIMPbiological_process
GO:0030837negative regulation of actin filament polymerizatiIDAbiological_process
GO:0010596negative regulation of endothelial cell migrationIDAbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0035385Roundabout signaling pathwayICbiological_process
GO:0001656metanephros developmentIEAbiological_process
GO:0002042cell migration involved in sprouting angiogenesisIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0060763mammary duct terminal end bud growthIEAbiological_process
GO:0045499chemorepellent activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0048754branching morphogenesis of a tubeIDAbiological_process
GO:0071672negative regulation of smooth muscle cell chemotaxIDAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0090024negative regulation of neutrophil chemotaxisIDAbiological_process
GO:0051058negative regulation of small GTPase mediated signaIDAbiological_process
GO:0021836chemorepulsion involved in postnatal olfactory bulIDAbiological_process
GO:0021972corticospinal neuron axon guidance through spinal IMPbiological_process
GO:0048846axon extension involved in axon guidanceIDAbiological_process
GO:0043394proteoglycan bindingIPImolecular_function
GO:0090288negative regulation of cellular response to growthIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0001657ureteric bud developmentIMPbiological_process
GO:0043116negative regulation of vascular permeabilityIDAbiological_process
GO:0071676negative regulation of mononuclear cell migrationIDAbiological_process
GO:0090260negative regulation of retinal ganglion cell axon IDAbiological_process
GO:0014912negative regulation of smooth muscle cell migratioIDAbiological_process
GO:0010593negative regulation of lamellipodium assemblyIDAbiological_process
GO:0050772positive regulation of axonogenesisTASbiological_process
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0005095GTPase inhibitor activityIDAmolecular_function