Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GPC1_HUMAN
Description:glypican 1 [Source:HGNC Symbol;Acc:4449]
Location:chr2 q37.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T447VEVDItKPDMTHPRD
S29DPASKsRSCGEGlypicanPhosphoSitePlus
Y39EVRQIyGAKGFGlypicanPhosphoSitePlus
S372RERPPsGTLEKGlypicanPhosphoSitePlus

Dephosphorylation site
GPC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264039A337DSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000264039Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
GPC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SLIT1_HUMANGPC1_HUMANligand -> receptorHPMR
SLIT2_HUMANGPC1_HUMANligand -> receptorHPMR
COIA1_HUMANGPC1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
GPC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0040037negative regulation of fibroblast growth factor reIEAbiological_process
GO:0005578proteinaceous extracellular matrixISScellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0031225anchored to membraneIEAcellular_component
GO:0014037Schwann cell differentiationISSbiological_process
GO:0005796Golgi lumenTAScellular_component
GO:0017134fibroblast growth factor bindingIEAmolecular_function
GO:0005768endosomeIEAcellular_component
GO:0006027glycosaminoglycan catabolic processTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0043236laminin bindingIEAmolecular_function
GO:0043202lysosomal lumenTAScellular_component
GO:0032288myelin assemblyISSbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0006024glycosaminoglycan biosynthetic processTASbiological_process
GO:0040037negative regulation of fibroblast growth factor reISSbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0017134fibroblast growth factor bindingISSmolecular_function
GO:2001016positive regulation of skeletal muscle cell differISSbiological_process
GO:0005507copper ion bindingIDAmolecular_function
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0043236laminin bindingISSmolecular_function
GO:0045121membrane raftIDAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:2001016positive regulation of skeletal muscle cell differIEAbiological_process
GO:0030200heparan sulfate proteoglycan catabolic processIDAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0043395heparan sulfate proteoglycan bindingIEAmolecular_function
GO:0030204chondroitin sulfate metabolic processTASbiological_process


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