Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SLIT1_HUMAN
Description:slit homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:11085]
Location:chr10 q24.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T74NGNNItRIHKNLRR_4PhosphoSitePlus
S553NNNEIsILEATLRR_4PhosphoSitePlus
T565MFKKLtHLKKILRR_4PhosphoSitePlus
Y332GAFSPyRKLRRPhosphoSitePlus

Dephosphorylation site
SLIT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000266058N1026ICOSMICOvarian Cancer21720365
ENSP00000266058H1247YCOSMICSkin Cancer21984974
ENSP00000266058P708SBIOMARTBreast Cancer21930507, 21930502
ENSP00000266058A464VCOSMICSkin Cancer21984974
ENSP00000266058I495FCOSMICOvarian Cancer21720365
ENSP00000266058Y1346*COSMICHead and Neck Cancer21798893
ENSP00000266058P701ACOSMICOvarian Cancer21720365
ENSP00000266058Q163ECOSMICOvarian Cancer21720365

Differential expressed protein
SLIT1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SLIT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SLIT1_HUMANGPC1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0048495Roundabout bindingIEAmolecular_function
GO:0008045motor neuron axon guidanceIMPbiological_process
GO:0048495Roundabout bindingIPImolecular_function
GO:0031290retinal ganglion cell axon guidanceIEAbiological_process
GO:0005615extracellular spaceNAScellular_component
GO:0007409axonogenesisIEAbiological_process
GO:0040023establishment of nucleus localizationIEAbiological_process
GO:0050919negative chemotaxisIEAbiological_process
GO:0021772olfactory bulb developmentIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0043395heparan sulfate proteoglycan bindingIEAmolecular_function
GO:0021510spinal cord developmentIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0050919negative chemotaxisIDAbiological_process
GO:0048846axon extension involved in axon guidanceIDAbiological_process
GO:0048853forebrain morphogenesisNASbiological_process
GO:0005509calcium ion bindingNASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0022028tangential migration from the subventricular zone IEAbiological_process
GO:0048843negative regulation of axon extension involved in IEAbiological_process
GO:0022029telencephalon cell migrationIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007411axon guidanceIDAbiological_process
GO:0051964negative regulation of synapse assemblyISSbiological_process
GO:0033563dorsal/ventral axon guidanceIEAbiological_process


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