Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHAN1_HUMAN
Description:SH3 and multiple ankyrin repeat domains 1 [Source:HGNC Symbol;Acc:15474]
Location:chr19 q13.33
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1533PPSPTsPRASEPhosphoSitePlus
S26EGGSEsDSSPDPhosphoSitePlus
S540GGPGGsLGSRGHPRD
S1512GRGPPsEDGPGPhosphoSitePlus
T946SSGRLtPSPRGPhosphoSitePlus
Y551RRRKLySAVPGPhosphoSitePlus
Y275GGSPNyKDRRGAnk_2PhosphoSitePlus
S15DEERHsASECPPhosphoSitePlus
S2007SLLPAsEHKVSHPRD
S948GRLTPsPRGGPPhosphoSitePlus
S24CPEGGsESDSSPhosphoSitePlus
S1506RAPVTsGRGPPPhosphoSitePlus
S17ERHSAsECPEGPhosphoSitePlus
S488SGTLRsASSPRPhosphoSitePlus
Y275GGSPNyKDRRGHPRD; phosphoELM
S1522GVPPPsPRRSVPhosphoSitePlus
S543GGSLGsRGRRRHPRD
T287TPLFHtAMVGGPhosphoSitePlus
Y1097ASAAMyVPARSPhosphoSitePlus

Dephosphorylation site
SHAN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000293441A569DHPIColorectal Cancer16959974
ENSP00000293441M762ICOSMICSkin Cancer21984974
ENSP00000293441R632QCOSMICHead and Neck Cancer21798893
ENSP00000293441G2026RSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000293441G2026RHPIColorectal Cancer16959974
ENSP00000293441P424fs*5COSMICHead and Neck Cancer21798893
ENSP00000293441A569DSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
SHAN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SHAN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SHAN1_HUMANLPHN1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042802identical protein bindingISSmolecular_function
GO:0071532ankyrin repeat bindingIEAmolecular_function
GO:0071625vocalization behaviorIMPbiological_process
GO:0035176social behaviorIEAbiological_process
GO:0060013righting reflexIEAbiological_process
GO:0046959habituationIEAbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0008328ionotropic glutamate receptor complexISScellular_component
GO:0016020membraneIDAcellular_component
GO:0050894determination of affectIMPbiological_process
GO:0032232negative regulation of actin filament bundle assemIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030160GKAP/Homer scaffold activityIEAmolecular_function
GO:0043005neuron projectionIEAcellular_component
GO:0045211postsynaptic membraneISScellular_component
GO:2000463positive regulation of excitatory postsynaptic memISSbiological_process
GO:0030160GKAP/Homer scaffold activityISSmolecular_function
GO:0030054cell junctionIEAcellular_component
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0007016cytoskeletal anchoring at plasma membraneNASbiological_process
GO:0014069postsynaptic densityISScellular_component
GO:0030425dendriteNAScellular_component
GO:0008306associative learningISSbiological_process
GO:0060076excitatory synapseISScellular_component
GO:0042048olfactory behaviorIEAbiological_process
GO:0097110scaffold protein bindingISSmolecular_function
GO:0045202synapseIEAcellular_component
GO:0035418protein localization to synapseISSbiological_process
GO:0097110scaffold protein bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0007616long-term memoryIEAbiological_process
GO:2000463positive regulation of excitatory postsynaptic memIEAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0043197dendritic spineISScellular_component
GO:0060997dendritic spine morphogenesisIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoISSbiological_process
GO:0017146N-methyl-D-aspartate selective glutamate receptor IEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0035255ionotropic glutamate receptor bindingIEAmolecular_function
GO:0060999positive regulation of dendritic spine developmentIEAbiological_process
GO:0060076excitatory synapseIEAcellular_component
GO:0007616long-term memoryISSbiological_process
GO:0031877somatostatin receptor bindingIEAmolecular_function
GO:0032403protein complex bindingIEAmolecular_function
GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoIEAbiological_process
GO:0008306associative learningIEAbiological_process
GO:0006461protein complex assemblyISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0035255ionotropic glutamate receptor bindingISSmolecular_function
GO:0050885neuromuscular process controlling balanceISSbiological_process
GO:0060074synapse maturationIEAbiological_process
GO:0035418protein localization to synapseIEAbiological_process
GO:0005886plasma membraneISScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0045211postsynaptic membraneIEAcellular_component
GO:0006461protein complex assemblyIEAbiological_process
GO:0071625vocalization behaviorIEAbiological_process
GO:0030159receptor signaling complex scaffold activityIEAmolecular_function
GO:0043005neuron projectionISScellular_component
GO:0060997dendritic spine morphogenesisISSbiological_process
GO:0071532ankyrin repeat bindingISSmolecular_function
GO:0005622intracellularNAScellular_component
GO:0017124SH3 domain bindingISSmolecular_function
GO:0008328ionotropic glutamate receptor complexIEAcellular_component
GO:0035176social behaviorIMPbiological_process


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