| UniProt/SwissProt ID: | SH3G1_HUMAN |
| Description: | SH3-domain GRB2-like 1 [Source:HGNC Symbol;Acc:10830] |
| Location: | chr19 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y315 | SCKALyDFEPE | Src | RegPhos |
| Y315 | SCKALyDFEPE | SRC | phosphoELM |
| Y315 | SCKALyDFEPE | FAK | phosphoELM; RegPhos |
| S288 | IAASSsFRSSD | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y315 | SCKALyDFEPE | SH3_1 | PhosphoSitePlus |
| S288 | IAASSsFRSSD | Exonuc_VII_L | PhosphoSitePlus; SysPTM |
| S287 | KIAASsSFRSS | Exonuc_VII_L | PhosphoSitePlus |
| T298 | DKPIRtPSRSM | PhosphoSitePlus | |
| S287 | KIAASsSFRSS | HPRD; phosphoELM | |
| S286 | PKIAAsSSFRS | HPRD | |
| Dephosphorylation site |
| SH3G1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000269886 | R290* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000269886 | Y225D | COSMIC | Ovarian Cancer | 20668451 |
| Differential expressed protein |
| SH3G1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SH3G1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FAK1_HUMAN | SH3G1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | SH3G1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007417 | central nervous system development | TAS | biological_process |
| GO:0008289 | lipid binding | IEA | molecular_function |
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0019902 | phosphatase binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0031901 | early endosome membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0051020 | GTPase binding | IEA | molecular_function |