| UniProt/SwissProt ID: | SESN1_HUMAN |
| Description: | sestrin 1 [Source:HGNC Symbol;Acc:21595] |
| Location: | chr6 q21 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S314 | MFVFSsDDEEV | PA26 | PhosphoSitePlus |
| S293 | DEEEAsQEEMA | PA26 | PhosphoSitePlus |
| S352 | DEEEAsQEEMA | HPRD | |
| S293 | DEEEAsQEEMA | phosphoELM | |
| Dephosphorylation site |
| SESN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000393762 | G104R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| SESN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SESN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | SESN1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SESN1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0006974 | response to DNA damage stimulus | TAS | biological_process |
| GO:0007050 | cell cycle arrest | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |