| UniProt/SwissProt ID: | SENP2_HUMAN |
| Description: | SUMO1/sentrin/SMT3 specific peptidase 2 [Source:HGNC Symbol;Acc:23116] |
| Location: | chr3 q27.2 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y216 | EEREKyRKLLE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S496 | LKYLDsMGQKG | Peptidase_C48 | PhosphoSitePlus |
| S34 | RRRSDsTLFST | PhosphoSitePlus | |
| S168 | GGRRHsKGNPE | PhosphoSitePlus | |
| Y130 | NGISDyPKIRV | PhosphoSitePlus | |
| S284 | RGPLCsLRSEK | PhosphoSitePlus | |
| T35 | RRSDStLFSTV | PhosphoSitePlus | |
| S344 | LRRKVsIIETK | PhosphoSitePlus | |
| S231 | SGHGNsVCPVT | PhosphoSitePlus | |
| Y239 | PVTSNyHSSQR | PhosphoSitePlus | |
| Y558 | CKYADyISRDK | Peptidase_C48 | PhosphoSitePlus |
| S292 | SEKRCsKGKIT | PhosphoSitePlus | |
| Y493 | KKCLKyLDSMG | Peptidase_C48 | PhosphoSitePlus |
| S333 | RLRLGsGSNGL | PhosphoSitePlus; HPRD | |
| S287 | LCSLRsEKRCS | PhosphoSitePlus | |
| Dephosphorylation site |
| SENP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296257 | P540L | COSMIC | Lung Cancer | 20668451 | ENSP00000296257 | W113C | COSMIC | Lung Cancer | 20668451 | ENSP00000296257 | E214D | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| SENP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SENP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SENP2_HUMAN | DVL1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03013 | RNA transport |
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0016604 | nuclear body | IEA | cellular_component |
| GO:0005643 | nuclear pore | IDA | cellular_component |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0009950 | dorsal/ventral axis specification | IEA | biological_process |
| GO:0051028 | mRNA transport | IEA | biological_process |
| GO:0008234 | cysteine-type peptidase activity | IEA | molecular_function |
| GO:0051246 | regulation of protein metabolic process | IEA | biological_process |
| GO:0032091 | negative regulation of protein binding | IEA | biological_process |
| GO:0016929 | SUMO-specific protease activity | IDA | molecular_function |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0035562 | negative regulation of chromatin binding | IEA | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0016926 | protein desumoylation | IEA | biological_process |
| GO:0031965 | nuclear membrane | IEA | cellular_component |
| GO:0030111 | regulation of Wnt receptor signaling pathway | NAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |