| UniProt/SwissProt ID: | SCNNG_HUMAN |
| Description: | sodium channel, non-voltage-gated 1, gamma subunit [Source:HGNC Symbol;Acc:10602] |
| Location: | chr16 p12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T629 | PPKYNtLRLER | PhosphoSitePlus | |
| S637 | LERAFsNQLTD | PhosphoSitePlus | |
| T109 | PYKYStVRHLL | ASC | PhosphoSitePlus |
| T641 | FSNQLtDTQML | PhosphoSitePlus | |
| S108 | NPYKYsTVRHL | ASC | PhosphoSitePlus |
| T98 | DFPAVtICNIN | ASC | PhosphoSitePlus |
| T622 | TQVPGtPPPKY | MAPK1 | HPRD |
| Dephosphorylation site |
| SCNNG_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000300061 | H112Y | COSMIC | Melanoma | 21499247 | ENSP00000300061 | T353N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000300061 | H280Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000300061 | P338L | COSMIC | Melanoma | 21499247 | ENSP00000300061 | H280Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000300061 | G58R | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000300061 | T18M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000300061 | T353N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000300061 | G58R | HPI | Colorectal Cancer | 16959974 | ENSP00000300061 | R631H | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| SCNNG_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SCNNG_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | SCNNG_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04742 | Taste transduction |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0035725 | sodium ion transmembrane transport | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005272 | sodium channel activity | TAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007588 | excretion | TAS | biological_process |
| GO:0005272 | sodium channel activity | IEA | molecular_function |
| GO:0006814 | sodium ion transport | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0050909 | sensory perception of taste | IEA | biological_process |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0050896 | response to stimulus | IEA | biological_process |
| GO:0006814 | sodium ion transport | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0050699 | WW domain binding | IPI | molecular_function |
| GO:0034706 | sodium channel complex | IEA | cellular_component |
| GO:0015280 | ligand-gated sodium channel activity | IEA | molecular_function |
| GO:0050699 | WW domain binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |