Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SC6A4_HUMAN
Description:solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 [Source:HGNC Symbol;Acc:11050]
Location:chr17 q11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T276WKGVKtSGKVVSNFPhosphoSitePlus
Y142LALGQyHRNGCSNFPhosphoSitePlus
T59GAGDDtRHSIP5HT_transporterPhosphoSitePlus
T81QGEREtWGKKVSNFPhosphoSitePlus
Y47QISNGySAVPS5HT_transporterPhosphoSitePlus
S611ERIIKsITPETPhosphoSitePlus; phosphoELM
T613IIKSItPETPTPhosphoSitePlus; phosphoELM
T616SITPEtPTEIPPhosphoSitePlus; phosphoELM
T276WKGVKtSGKVVphosphoELM
T81QGEREtWGKKVphosphoELM

Dephosphorylation site
SC6A4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385822Q42KBIOMARTBreast Cancer21930507, 21930502
ENSP00000261707Q42KBIOMARTBreast Cancer21930507, 21930502
ENSP00000261707M1ICOSMICSkin Cancer21984974
ENSP00000261707P196SCOSMICMelanoma21499247

Differential expressed protein
SC6A4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SC6A4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANSC6A4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04726Serotonergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051259protein oligomerizationIEAbiological_process
GO:0046621negative regulation of organ growthIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0042310vasoconstrictionIEAbiological_process
GO:0015222serotonin transmembrane transporter activityIMPmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0042713sperm ejaculationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0015844monoamine transportIDAbiological_process
GO:0032227negative regulation of synaptic transmission, dopaIEAbiological_process
GO:0045787positive regulation of cell cycleIEAbiological_process
GO:0009636response to toxinIDAbiological_process
GO:0017075syntaxin-1 bindingIEAmolecular_function
GO:0005335serotonin:sodium symporter activityIEAmolecular_function
GO:0005328neurotransmitter:sodium symporter activityIEAmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0007613memoryIEAbiological_process
GO:0048854brain morphogenesisIEAbiological_process
GO:0006837serotonin transportIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0017137Rab GTPase bindingIPImolecular_function
GO:0010008endosome membraneIEAcellular_component
GO:0007623circadian rhythmIEAbiological_process
GO:0051015actin filament bindingIEAmolecular_function
GO:0017022myosin bindingIEAmolecular_function
GO:0007584response to nutrientIEAbiological_process
GO:0021794thalamus developmentIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0051260protein homooligomerizationIEAbiological_process
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0019811cocaine bindingIEAmolecular_function
GO:0051259protein oligomerizationISSbiological_process
GO:0051610serotonin uptakeIEAbiological_process
GO:0008504monoamine transmembrane transporter activityIDAmolecular_function
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0006836neurotransmitter transportIEAbiological_process
GO:0012505endomembrane systemIDAcellular_component
GO:0050998nitric-oxide synthase bindingIEAmolecular_function
GO:0035176social behaviorIEAbiological_process
GO:0021941negative regulation of cerebellar granule cell preIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0071321cellular response to cGMPIEAbiological_process
GO:0006837serotonin transportIDAbiological_process


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