Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SC6A2_HUMAN
Description:solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 [Source:HGNC Symbol;Acc:11048]
Location:chr16 q12.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S194KLLNGsVLGNHHPRD
S259KGVKTsGKVVWSNFPhosphoSitePlus
T30LRARKtAELLVPhosphoSitePlus
T258WKGVKtSGKVVSNFPhosphoSitePlus

Dephosphorylation site
SC6A2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369237E223KCOSMICLung Cancer20668451
ENSP00000369237V10LCOSMICOvarian Cancer21720365
ENSP00000369237E212*TCGAOvarian Cancer21720365, 18772890
ENSP00000369237C176*COSMICLung Cancer20668451
ENSP00000369237W80CCOSMICLung Cancer20668451
ENSP00000369237R587GTCGAOvarian Cancer21720365, 18772890
ENSP00000369237E212*COSMICOvarian Cancer21720365
ENSP00000369237L472PCOSMICHead and Neck Cancer21798893
ENSP00000369237G260ECOSMICLung Cancer20668451
ENSP00000457473R587GTCGAOvarian Cancer21720365, 18772890
ENSP00000369237R587GCOSMICOvarian Cancer21720365
ENSP00000457473E212*TCGAOvarian Cancer21720365, 18772890

Differential expressed protein
SC6A2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SC6A2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PHX2A_HUMANSC6A2_HUMANTF -> target geneTRANSFAC
HXA5_HUMANSC6A2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
SC6A2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneIEAcellular_component
GO:0005334norepinephrine:sodium symporter activityTASmolecular_function
GO:0005328neurotransmitter:sodium symporter activityIEAmolecular_function
GO:0006810transportTASbiological_process
GO:0016020membraneTAScellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008504monoamine transmembrane transporter activityIDAmolecular_function
GO:0006836neurotransmitter transportIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0015844monoamine transportIDAbiological_process
GO:0048265response to painIEAbiological_process
GO:0005515protein bindingIPImolecular_function


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