| UniProt/SwissProt ID: | SC6A2_HUMAN |
| Description: | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 [Source:HGNC Symbol;Acc:11048] |
| Location: | chr16 q12.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S194 | KLLNGsVLGNH | HPRD | |
| S259 | KGVKTsGKVVW | SNF | PhosphoSitePlus |
| T30 | LRARKtAELLV | PhosphoSitePlus | |
| T258 | WKGVKtSGKVV | SNF | PhosphoSitePlus |
| Dephosphorylation site |
| SC6A2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000369237 | E223K | COSMIC | Lung Cancer | 20668451 | ENSP00000369237 | V10L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000369237 | E212* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000369237 | C176* | COSMIC | Lung Cancer | 20668451 | ENSP00000369237 | W80C | COSMIC | Lung Cancer | 20668451 | ENSP00000369237 | R587G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000369237 | E212* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000369237 | L472P | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000369237 | G260E | COSMIC | Lung Cancer | 20668451 | ENSP00000457473 | R587G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000369237 | R587G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000457473 | E212* | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| SC6A2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SC6A2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PHX2A_HUMAN | SC6A2_HUMAN | TF -> target gene | TRANSFAC |
| HXA5_HUMAN | SC6A2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SC6A2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0005334 | norepinephrine:sodium symporter activity | TAS | molecular_function |
| GO:0005328 | neurotransmitter:sodium symporter activity | IEA | molecular_function |
| GO:0006810 | transport | TAS | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0008504 | monoamine transmembrane transporter activity | IDA | molecular_function |
| GO:0006836 | neurotransmitter transport | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0015844 | monoamine transport | IDA | biological_process |
| GO:0048265 | response to pain | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |