Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:S4A4_HUMAN
Description:solute carrier family 4, sodium bicarbonate cotransporter, member 4 [Source:HGNC Symbol;Acc:11030]
Location:chr4 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T49RHKRKtGHKEKPhosphoSitePlus
T163DKVTYtLLRKHHPRD
Y64RISENySDKSDPhosphoSitePlus
S1061PFLSDsKPSDRFmp27_WPPWPhosphoSitePlus
S233GKTVSsASRMFBand_3_cytoPhosphoSitePlus
S232IGKTVsSASRMBand_3_cytoPhosphoSitePlus
Y407KRKNMySGGENPhosphoSitePlus
S245NPDNGsPAMTHHPRD
T1077FLERHtSC___PhosphoSitePlus
S1034SDNDDsDCPYSRegPhos
Y1038DSDCPySEKVPFmp27_WPPWPhosphoSitePlus
S256RNLTSsSLNDIBand_3_cytoPhosphoSitePlus
S1026KKKKGsLDSDNPKACaRegPhos
T254THRNLtSSSLNRegPhos
S65ISENYsDKSDIPhosphoSitePlus
S12LDRGAsFLKHVPhosphoSitePlus
T207DKVTYtLLRKHHPRD
Y941QPDFIyLRHVPHCO3_cotranspPhosphoSitePlus
S245NPDNGsPAMTHBand_3_cytoPhosphoSitePlus
S213NLTSSsLNDISHPRD
S1034SDNDDsDCPYSFmp27_WPPWPhosphoSitePlus
T1071RERSPtFLERHPhosphoSitePlus
S257NLTSSsLNDISBand_3_cytoPhosphoSitePlus
S68NYSDKsDIENAPhosphoSitePlus
S212RNLTSsSLNDIHPRD
Y30GHHTIyIGVHVPhosphoSitePlus; RegPhos
S1025SDRERsPTFLEHPRD
S1029KGSLDsDNDDSRegPhos
T28VEGHHtIYIGVPhosphoSitePlus
S982KKKKGsLDSDNPRKACAHPRD
S223KSNLRsLADIGBand_3_cytoPhosphoSitePlus
S1026KKKKGsLDSDNFmp27_WPPWPhosphoSitePlus
S256RNLTSsSLNDIHPRD
S1026KKKKGsLDSDNPKA_groupphosphoELM; RegPhos
T207DKVTYtLLRKHBand_3_cytoPhosphoSitePlus
T249GSPAMtHRNLTBand_3_cytoPhosphoSitePlus
S257NLTSSsLNDISHPRD; RegPhos
S211HRNLTsSSLNDHPRD
S255HRNLTsSSLNDBand_3_cytoPhosphoSitePlus
Y206KDKVTyTLLRKBand_3_cytoPhosphoSitePlus
S201NPDNGsPAMTHHPRD
T49RHKRKtGHKEKPKA_groupRegPhos
S1064SDSKPsDRERSFmp27_WPPWPhosphoSitePlus
T254THRNLtSSSLNBand_3_cytoPhosphoSitePlus
S1069SDRERsPTFLEPhosphoSitePlus; HPRD
S262SLNDIsDKPEKRegPhos
S1078LERHTsC____PhosphoSitePlus
S1029KGSLDsDNDDSFmp27_WPPWPhosphoSitePlus
S255HRNLTsSSLNDHPRD

Dephosphorylation site
S4A4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000344272H386LCOSMICOvarian Cancer21720365
ENSP00000344272P999ACOSMICHead and Neck Cancer21798893
ENSP00000264485P901HTCGAOvarian Cancer21720365, 18772890
ENSP00000344272G8ECOSMICSkin Cancer21984974
ENSP00000344272L794FCOSMICHead and Neck Cancer21984974
ENSP00000344272P857HCOSMICOvarian Cancer21720365
ENSP00000344272G339ECOSMICSkin Cancer21984974
ENSP00000344272W781*COSMICOvarian Cancer21720365
ENSP00000264485W825*TCGAOvarian Cancer21720365, 18772890
ENSP00000264485H430LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
S4A4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
S4A4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANS4A4_HUMANkinase -> substrateHPRD
ZAGL2_HUMANS4A4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa04964Proximal tubule bicarbonate reclamation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0015701bicarbonate transportTASbiological_process
GO:0008509anion transmembrane transporter activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0015701bicarbonate transportIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005215transporter activityIEAmolecular_function
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0008510sodium:bicarbonate symporter activityTASmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0006810transportTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0006811ion transportTASbiological_process
GO:0006814sodium ion transportIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005452inorganic anion exchanger activityIEAmolecular_function
GO:0006820anion transportIEAbiological_process


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