| UniProt/SwissProt ID: | S4A4_HUMAN |
| Description: | solute carrier family 4, sodium bicarbonate cotransporter, member 4 [Source:HGNC Symbol;Acc:11030] |
| Location: | chr4 q13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T49 | RHKRKtGHKEK | PhosphoSitePlus | |
| T163 | DKVTYtLLRKH | HPRD | |
| Y64 | RISENySDKSD | PhosphoSitePlus | |
| S1061 | PFLSDsKPSDR | Fmp27_WPPW | PhosphoSitePlus |
| S233 | GKTVSsASRMF | Band_3_cyto | PhosphoSitePlus |
| S232 | IGKTVsSASRM | Band_3_cyto | PhosphoSitePlus |
| Y407 | KRKNMySGGEN | PhosphoSitePlus | |
| S245 | NPDNGsPAMTH | HPRD | |
| T1077 | FLERHtSC___ | PhosphoSitePlus | |
| S1034 | SDNDDsDCPYS | RegPhos | |
| Y1038 | DSDCPySEKVP | Fmp27_WPPW | PhosphoSitePlus |
| S256 | RNLTSsSLNDI | Band_3_cyto | PhosphoSitePlus |
| S1026 | KKKKGsLDSDN | PKACa | RegPhos |
| T254 | THRNLtSSSLN | RegPhos | |
| S65 | ISENYsDKSDI | PhosphoSitePlus | |
| S12 | LDRGAsFLKHV | PhosphoSitePlus | |
| T207 | DKVTYtLLRKH | HPRD | |
| Y941 | QPDFIyLRHVP | HCO3_cotransp | PhosphoSitePlus |
| S245 | NPDNGsPAMTH | Band_3_cyto | PhosphoSitePlus |
| S213 | NLTSSsLNDIS | HPRD | |
| S1034 | SDNDDsDCPYS | Fmp27_WPPW | PhosphoSitePlus |
| T1071 | RERSPtFLERH | PhosphoSitePlus | |
| S257 | NLTSSsLNDIS | Band_3_cyto | PhosphoSitePlus |
| S68 | NYSDKsDIENA | PhosphoSitePlus | |
| S212 | RNLTSsSLNDI | HPRD | |
| Y30 | GHHTIyIGVHV | PhosphoSitePlus; RegPhos | |
| S1025 | SDRERsPTFLE | HPRD | |
| S1029 | KGSLDsDNDDS | RegPhos | |
| T28 | VEGHHtIYIGV | PhosphoSitePlus | |
| S982 | KKKKGsLDSDN | PRKACA | HPRD |
| S223 | KSNLRsLADIG | Band_3_cyto | PhosphoSitePlus |
| S1026 | KKKKGsLDSDN | Fmp27_WPPW | PhosphoSitePlus |
| S256 | RNLTSsSLNDI | HPRD | |
| S1026 | KKKKGsLDSDN | PKA_group | phosphoELM; RegPhos |
| T207 | DKVTYtLLRKH | Band_3_cyto | PhosphoSitePlus |
| T249 | GSPAMtHRNLT | Band_3_cyto | PhosphoSitePlus |
| S257 | NLTSSsLNDIS | HPRD; RegPhos | |
| S211 | HRNLTsSSLND | HPRD | |
| S255 | HRNLTsSSLND | Band_3_cyto | PhosphoSitePlus |
| Y206 | KDKVTyTLLRK | Band_3_cyto | PhosphoSitePlus |
| S201 | NPDNGsPAMTH | HPRD | |
| T49 | RHKRKtGHKEK | PKA_group | RegPhos |
| S1064 | SDSKPsDRERS | Fmp27_WPPW | PhosphoSitePlus |
| T254 | THRNLtSSSLN | Band_3_cyto | PhosphoSitePlus |
| S1069 | SDRERsPTFLE | PhosphoSitePlus; HPRD | |
| S262 | SLNDIsDKPEK | RegPhos | |
| S1078 | LERHTsC____ | PhosphoSitePlus | |
| S1029 | KGSLDsDNDDS | Fmp27_WPPW | PhosphoSitePlus |
| S255 | HRNLTsSSLND | HPRD | |
| Dephosphorylation site |
| S4A4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000344272 | H386L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000344272 | P999A | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264485 | P901H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000344272 | G8E | COSMIC | Skin Cancer | 21984974 | ENSP00000344272 | L794F | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000344272 | P857H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000344272 | G339E | COSMIC | Skin Cancer | 21984974 | ENSP00000344272 | W781* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264485 | W825* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000264485 | H430L | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| S4A4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| S4A4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | S4A4_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | S4A4_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04972 | Pancreatic secretion |
| hsa04976 | Bile secretion |
| hsa04964 | Proximal tubule bicarbonate reclamation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015701 | bicarbonate transport | TAS | biological_process |
| GO:0008509 | anion transmembrane transporter activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0015701 | bicarbonate transport | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005215 | transporter activity | IEA | molecular_function |
| GO:0016323 | basolateral plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008510 | sodium:bicarbonate symporter activity | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006810 | transport | TAS | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0006811 | ion transport | TAS | biological_process |
| GO:0006814 | sodium ion transport | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005452 | inorganic anion exchanger activity | IEA | molecular_function |
| GO:0006820 | anion transport | IEA | biological_process |