Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RYR2_HUMAN
Description:ryanodine receptor 2 (cardiac) [Source:HGNC Symbol;Acc:10484]
Location:chr1 q43
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1428TSTYYySVRIFSPRYPhosphoSitePlus
S2808RTRRIsQTSQVPRKACAHPRD
S4758LRTILsSVTHNIon_transPhosphoSitePlus
S3497AKNRFsLKDTEPhosphoSitePlus
Y2202CRFLCyFCRISRYDR_ITPRPhosphoSitePlus
Y196YLHLSyGNGSLIns145_P3_recPhosphoSitePlus
S2814QTSQVsVDAAHPhosphoSitePlus; phosphoELM
S2808RTRRIsQTSQVPhosphoSitePlus; phosphoELM
Y2038VEKVTyLKKKQPhosphoSitePlus
Y823GYAPCyEAVLPPhosphoSitePlus
T3501FSLKDtEDEVRPhosphoSitePlus
T2529VLPLLtRCAPLPhosphoSitePlus
S4622ITEQPsEDDIKPhosphoSitePlus
S4695KDSSLsAVLNSPhosphoSitePlus
Y3285ILKIIyNNLGIPhosphoSitePlus
S4311FRIICsLLLGGTMPhosphoSitePlus
T2522NRYLCtAVLPLPhosphoSitePlus
Y4779LAVVVyLYTVVTM; Ion_transPhosphoSitePlus
S2808RTRRIsQTSQVCaMK2aRegPhos
S2751IYSDSsKVQPLHPRD
S3437ITDTKsKMSKAPhosphoSitePlus
S2031RGRLLsLVEKVPKA_groupphosphoELM; RegPhos
S2808RTRRIsQTSQVCaMK_group RegPhos
Y1427QTSTYyYSVRISPRYPhosphoSitePlus
T4755FKTLRtILSSVIon_transPhosphoSitePlus
Y4944YVWKMyQERCWPhosphoSitePlus
Y1944NQRFRyNEVMQPhosphoSitePlus
T1176HTMMFtLNGEISPRYPhosphoSitePlus
S3303RLAVFsQPIINPhosphoSitePlus
T4752AMGFKtLRTILIon_transPhosphoSitePlus
S2073RWAQEsVIEDPPhosphoSitePlus
Y3367LARDLyAFYPLPhosphoSitePlus
T1317EVFSKtVAGGLPhosphoSitePlus
S2808RTRRIsQTSQVCaM-KII_alphaphosphoELM
T2781KESLKtMLAWGRyRPhosphoSitePlus
S2808RTRRIsQTSQVPKA_groupphosphoELM; RegPhos
T4761ILSSVtHNGKQIon_transPhosphoSitePlus
Y3370DLYAFyPLLIRPhosphoSitePlus
Y2923EKRFAySFLQQPhosphoSitePlus
S2808RTRRIsQTSQVPKACaRegPhos
Y3459RKGDRySMQTSPhosphoSitePlus
Y4705SIDVKyQMWKLPhosphoSitePlus
S4317LLLGGsLVEGAPhosphoSitePlus
S2363SRDGPsPNSGSPhosphoSitePlus
S2031RGRLLsLVEKVPhosphoSitePlus
T1172DMNEHtMMFTLSPRYPhosphoSitePlus
S406DGISLsRSQHEMIRPhosphoSitePlus
Y2519LALNRyLCTAVPhosphoSitePlus
Y4391REGGQyKLIPHRR_TM4-6PhosphoSitePlus

Dephosphorylation site
RYR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355533A266TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000355533H3082NTCGAOvarian Cancer21720365, 18772890
ENSP00000355533A2498VTCGAOvarian Cancer21720365, 18772890
ENSP00000355533E4906VTCGAOvarian Cancer21720365, 18772890
ENSP00000355533L730PTCGAOvarian Cancer21720365, 18772890
ENSP00000355533N4399STCGAOvarian Cancer21720365, 18772890
ENSP00000355533E3487DTCGAOvarian Cancer21720365, 18772890
ENSP00000355533R2418WBIOMARTBreast Cancer21930507, 21930502
ENSP00000355533H1670QTCGAOvarian Cancer21720365, 18772890
ENSP00000355533A2936GTCGAOvarian Cancer21720365, 18772890
ENSP00000355533R122HBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000355533V3045ETCGAOvarian Cancer21720365, 18772890
ENSP00000355533V613ITCGAOvarian Cancer21720365, 18772890
ENSP00000355533S404*BIOMARTBreast Cancer21930507, 21930502
ENSP00000355533A2817TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000355533A3807VBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000355533D3896VTCGAOvarian Cancer21720365, 18772890
ENSP00000355533K1745TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
RYR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S2814ISQTSQVsVDAAHGYatrial fibrillation20056922PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANRYR2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa04972Pancreatic secretion
hsa04020Calcium signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060048cardiac muscle contractionIMPbiological_process
GO:0031000response to caffeineIEAbiological_process
GO:0014701junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0006816calcium ion transportIDAbiological_process
GO:0060402calcium ion transport into cytosolTASbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0003220left ventricular cardiac muscle tissue morphogenesIEAbiological_process
GO:0002027regulation of heart rateIEAbiological_process
GO:0010460positive regulation of heart rateIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0033017sarcoplasmic reticulum membraneIEAcellular_component
GO:0051480cytosolic calcium ion homeostasisISSbiological_process
GO:0060401cytosolic calcium ion transportIEAbiological_process
GO:0010881regulation of cardiac muscle contraction by regulaIEAbiological_process
GO:0051775response to redox stateIDAbiological_process
GO:0016529sarcoplasmic reticulumIEAcellular_component
GO:0019722calcium-mediated signalingIEAbiological_process
GO:0016529sarcoplasmic reticulumIDAcellular_component
GO:0005219ryanodine-sensitive calcium-release channel activiIEAmolecular_function
GO:0086029Purkinje myocyte to ventricular cardiac muscle celIEAbiological_process
GO:0034704calcium channel complexIDAcellular_component
GO:0006811ion transportIEAbiological_process
GO:0030018Z discIEAcellular_component
GO:0006874cellular calcium ion homeostasisISSbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0051209release of sequestered calcium ion into cytosolISSbiological_process
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0005218intracellular ligand-gated calcium channel activitIEAmolecular_function
GO:0043234protein complexIDAcellular_component
GO:0008627intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0005262calcium channel activityISSmolecular_function
GO:0043924suramin bindingIMPmolecular_function
GO:0005218intracellular ligand-gated calcium channel activitISSmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0034236protein kinase A catalytic subunit bindingIDAmolecular_function
GO:0055085transmembrane transportIEAbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0005216ion channel activityIEAmolecular_function
GO:0005886plasma membraneISScellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0031000response to caffeineIDAbiological_process
GO:0003143embryonic heart tube morphogenesisIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043621protein self-associationIEAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0015278calcium-release channel activityIDAmolecular_function
GO:0034237protein kinase A regulatory subunit bindingIDAmolecular_function
GO:0006816calcium ion transportIEAbiological_process
GO:0014808release of sequestered calcium ion into cytosol byIEAbiological_process
GO:0005513detection of calcium ionIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0086005regulation of ventricular cardiac muscle cell actiIEAbiological_process
GO:0003300cardiac muscle hypertrophyIEAbiological_process
GO:0086094positive regulation of ryanodine-sensitive calciumIEAbiological_process
GO:0071313cellular response to caffeineIEAbiological_process
GO:0019722calcium-mediated signalingISSbiological_process
GO:0070296sarcoplasmic reticulum calcium ion transportTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005262calcium channel activityIEAmolecular_function
GO:0030509BMP signaling pathwayIEAbiological_process